Lipopolysaccharides: structural principles and biologic activities

Structural principles of the three regions of the lipopolysaccharide molecule are briefly discussed. One of the recently available, chemically synthesized lipid A analogues has been tested for biologic activities. The preparation was found to be toxic, pyrogenic, and mitogenic. The amounts, however,...

Full description

Saved in:
Bibliographic Details
Published inReviews of infectious diseases Vol. 6; no. 4; p. 428
Main Authors Lüderitz, O, Tanamoto, K, Galanos, C, McKenzie, G R, Brade, H, Zähringer, U, Rietschel, E T, Kusumoto, S, Shiba, T
Format Journal Article
LanguageEnglish
Published United States 01.07.1984
Subjects
Animals
Lipid A - immunology
Lipid A - toxicity
Lipopolysaccharides - analysis
Mice
Mitogens - pharmacology
Pyrogens - toxicity
Rabbits
Structure-Activity Relationship
Online AccessGet more information

Cover

More Information
Summary:Structural principles of the three regions of the lipopolysaccharide molecule are briefly discussed. One of the recently available, chemically synthesized lipid A analogues has been tested for biologic activities. The preparation was found to be toxic, pyrogenic, and mitogenic. The amounts, however, needed for expression of effects similar to those of lipid A were about 500 times higher. These investigations are aimed at verifying the proposed structure of lipid A and at evaluating structure-activity relationships.
ISSN:0162-0886