FR227244, a Novel Antifungal Antibiotic from Myrothecium cinctum No. 002 I. Taxonomy, Fermentation, Isolation and Physico-chemical Properties

A novel antifungal antibiotic, FR227244, was isolated from the culture broth of a fungal strain No. 002. The strain was identified as Myrothecium cinctum from morphological and physiological characteristics. This compound was isolated from the culture broth by solvent extraction, HP-20 and YMC ODS g...

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Published inJournal of antibiotics Vol. 57; no. 12; pp. 780 - 787
Main Authors KOBAYASHI, MOTOO, KANASAKI, RYUICHI, EZAKI, MASAMI, SAKAMOTO, KAZUTOSHI, TAKASE, SHIGEHIRO, FUJIE, AKIHIKO, HINO, MOTOHIRO, HORI, YASUHIRO
Format Journal Article
LanguageEnglish
Published TOKYO JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 25.12.2004
Japan Antibiotics Research Assoc
Subjects
Biotechnology & Applied Microbiology
Immunology
Life Sciences & Biomedicine
Microbiology
Pharmacology & Pharmacy
Science & Technology
AGENT
ZALERION-ARBORICOLA
PNEUMOCANDINS
ASCOTRICHA-AMPHITRICHA
ASCOSTEROSIDE
DISCOVERY
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Summary:A novel antifungal antibiotic, FR227244, was isolated from the culture broth of a fungal strain No. 002. The strain was identified as Myrothecium cinctum from morphological and physiological characteristics. This compound was isolated from the culture broth by solvent extraction, HP-20 and YMC ODS gel column chromatographies, and n-hexane precipitation. FR227244 is a white powder which melts at 210-211°C and possesses the molecular formula C38H58O11. FR227244 is a novel triterpene glycoside with antifungal activity against Aspergillus fumigatus. The effects of FR227244 on the morphology of A. fumigatus were shown to be similar to those of FR901379 which is a known 1, 3-β-glucan synthase inhibitor.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.57.780