EFFECT OF PROPHYLACTIC TREATMENT BY LEUKOTORIENE RECEPTOR ANTAGONIST ON JAPANESE CEDAR POLLINOSIS OF PRE- AND POST-SCHOOL CHILDREN JAPANESE CEDAR POLLINOSIS

• Published in: Arerugi Vol. 65; no. 1; p. 57
• Main Authors: Matsune, Shoji, Saruya, Shoji, Sawaki, Seiij, Otsuka, Hirokuni, Oyama, Yoshio, Minowa, Hitoshi, Koyama, Mamoru, Ikui, Akihiro, Yoshioka, Yuma, Wakayama, Nozomu, Ishida, Mariko, Sekine, Kuwon, Yamaguchi, Satoshi, Okubo, Kimihiro
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.02.2016
• Subjects: Child; Child, Preschool; Cryptomeria - immunology; Female; Humans; Leukotriene Antagonists - therapeutic use; Male; Pollen - immunology; Quality of Life; Receptors, Leukotriene - immunology; Rhinitis, Allergic, Seasonal - immunology; Rhinitis, Allergic, Seasonal - prevention & control
• ISSN: 0021-4884
• DOI: 10.15036/arerugi.65.57

Backgroud: It has already been reported that the prophylactic treatment by leukotoriene receptor antagonists is more effective on reducing symptoms of Japanese cedar pollinosis than the authentic treatment after the pollen dispersal. However, the treatment above has never evaluated in children cases around school age in ENT out-patient clinic. This study about the prophylactic treatment was planned to focus on the effect in the generation of pre- and post-elementary school entrance. Children of pre- and post-elementary school entrance were enrolled for this study. This study was achieved in seasons of Japanese cedar pollinosis both in 2013 and 2014, and was designed as the comparison of clinical symptoms and quality of life in between two such groups as one group with the prophylactic treatment and another with the authentic treatment. Efficacy of prophylactic treatment by leukotoriene receptor antagonists was elucidated as follows; quality of sleep was significantly better both in 2013 and 2014, and more kinds of clinical symptoms or quality of life impairments were significantly more suppressed than in the group with the authentic treatment in 2014 when less pollen was dispersed. Even in the children of pre- and post-elementary school entrance, the prophylactic treatment by leukotoriene receptor antagonists is more effective on reducing symptoms of Japanese cedar pollinosis than the authentic treatment.