運動および電気刺激による認知症予防の可能性
身体活動の低下は認知症発症に対する人口寄与リスクが高く，認知症予防の中核的な介入手段として運動があげられる。運動習慣の獲得によって高齢者の認知機能の向上が期待できるが，そのためには適切な運動処方と長期的に運動を継続するためのモチベーションを保持する必要があり，行動変容を効果的に生じさせるための研究が必要とされている。また，行動変容が期待できない対象者には受動的に実施可能な電気刺激による脳機能保持の可能性が示唆されている。日本老年療法学会の会員を中心として，これらの研究推進が期待される。...
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| Published in | 日本老年療法学会誌 Vol. 3; pp. 1 - 4 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本老年療法学会
20.05.2024
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| Online Access | Get full text |
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| Abstract | 身体活動の低下は認知症発症に対する人口寄与リスクが高く，認知症予防の中核的な介入手段として運動があげられる。運動習慣の獲得によって高齢者の認知機能の向上が期待できるが，そのためには適切な運動処方と長期的に運動を継続するためのモチベーションを保持する必要があり，行動変容を効果的に生じさせるための研究が必要とされている。また，行動変容が期待できない対象者には受動的に実施可能な電気刺激による脳機能保持の可能性が示唆されている。日本老年療法学会の会員を中心として，これらの研究推進が期待される。 |
|---|---|
| AbstractList | 身体活動の低下は認知症発症に対する人口寄与リスクが高く，認知症予防の中核的な介入手段として運動があげられる。運動習慣の獲得によって高齢者の認知機能の向上が期待できるが，そのためには適切な運動処方と長期的に運動を継続するためのモチベーションを保持する必要があり，行動変容を効果的に生じさせるための研究が必要とされている。また，行動変容が期待できない対象者には受動的に実施可能な電気刺激による脳機能保持の可能性が示唆されている。日本老年療法学会の会員を中心として，これらの研究推進が期待される。 |
| Author | 島田, 裕之 |
| Author_xml | – sequence: 1 fullname: 島田, 裕之 organization: 国立長寿医療研究センター研究所老年学・社会科学研究センター予防老年学研究部 |
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| References_xml | – reference: 10) Luo Y, Yang H, Yan X, Wu Y, Wei G, Wu X, et al. Transcranial Direct Current Stimulation Alleviates Neurovascular Unit Dysfunction in Mice With Preclinical Alzheimer's Disease. Front Aging Neurosci. 2022; 14: 857415. – reference: 14) Sofi F, Valecchi D, Bacci D, Abbate R, Gensini GF, Casini A, et al. Physical activity and risk of cognitive decline: a meta-analysis of prospective studies. J Intern Med. 2011; 269: 107-17. – reference: 16) Chou YH, Ton That V, Sundman M. A systematic review and meta-analysis of rTMS effects on cognitive enhancement in mild cognitive impairment and Alzheimer's disease. Neurobiol Aging. 2020; 86: 1-10. – reference: 4) Rolland Y, Abellan van Kan G, Vellas B. Physical activity and Alzheimer's disease: from prevention to therapeutic perspectives. Journal of the American Medical Directors Association. 2008; 9: 390-405. – reference: 13) Chen X, Dong GY, Wang LX. High-frequency transcranial magnetic stimulation protects APP/PS1 mice against Alzheimer's disease progress by reducing APOE and enhancing autophagy. Brain Behav. 2020; 10: e01740. – reference: 2) Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020; 396: 413-46. – reference: 5) Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, et al. Exercise training increases size of hippocampus and improves memory. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108: 3017-22. – reference: 11) Marcello E, Borroni B, Pelucchi S, Gardoni F, Di Luca M. ADAM10 as a therapeutic target for brain diseases: from developmental disorders to Alzheimer's disease. Expert Opin Ther Targets. 2017; 21: 1017-26. – reference: 9) De Miguel Z, Khoury N, Betley MJ, Lehallier B, Willoughby D, Olsson N, et al. Exercise plasma boosts memory and dampens brain inflammation via clusterin. Nature. 2021; 600: 494-9. – reference: 3) Barnes DE, Yaffe K. The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet neurology. 2011; 10: 819-28. – reference: 6) Shimada H, Makizako H, Doi T, Yoshida D, Tsutsumimoto K, Anan Y, et al. A large, cross-sectional observational study of serum BDNF, cognitive function, and mild cognitive impairment in the elderly. Front Aging Neurosci. 2014; 6: 69. – reference: 1) Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, et al. Dementia prevention, intervention, and care. Lancet. 2017. – reference: 12) Jang Y, Lee SH, Lee B, Jung S, Khalid A, Uchida K, et al. TRPM2, a Susceptibility Gene for Bipolar Disorder, Regulates Glycogen Synthase Kinase-3 Activity in the Brain. J Neurosci. 2015; 35: 11811-23. – reference: 7) Shimada H, Makizako H, Doi T, Park H, Tsutsumimoto K, Verghese J, et al. Effects of Combined Physical and Cognitive Exercises on Cognition and Mobility in Patients With Mild Cognitive Impairment: A Randomized Clinical Trial. J Am Med Dir Assoc. 2017. – reference: 15) Northey JM, Cherbuin N, Pumpa KL, Smee DJ, Rattray B. Exercise interventions for cognitive function in adults older than 50: a systematic review with meta-analysis. Br J Sports Med. 2017. – reference: 17) Sabia S, Dugravot A, Dartigues JF, Abell J, Elbaz A, Kivimaki M, et al. Physical activity, cognitive decline, and risk of dementia: 28 year follow-up of Whitehall II cohort study. BMJ. 2017; 357: j2709. – reference: 8) Gates N, Fiatarone Singh MA, Sachdev PS, Valenzuela M. The effect of exercise training on cognitive function in older adults with mild cognitive impairment: a meta-analysis of randomized controlled trials. Am J Geriatr Psychiatry. 2013; 21: 1086-97. |
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| SubjectTerms | 脳刺激 認知症 身体活動 軽度認知障害 運動 |
| Title | 運動および電気刺激による認知症予防の可能性 |
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| ispartofPNX | 日本老年療法学会誌, 2024/05/20, Vol.3, pp.1-4 |
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