Acute complete bilateral ophthalmoplegia and ptosis without ataxia or areflexia associated with serum anti‐GQ1b antibody

We report the case of a 65‐year‐old woman who presented with acute complete bilateral ophthalmoplegia and ptosis. Deep tendon reflexes were normal and there were no signs of ataxia. On laboratory examination, the patient had vitamin B1 deficiency; however, symptoms did not improve after fursultiamin...

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Bibliographic Details
Published inNeurology and clinical neuroscience Vol. 5; no. 6; pp. 178 - 180
Main Authors Tsuzaki, Koji, Tatsuno, Kentaro, Inoue, Manabu, Tachibana, Naoko, Hamano, Toshiaki
Format Journal Article
LanguageEnglish
Published Tokyo Wiley Subscription Services, Inc 01.11.2017
Subjects
acute ophthalmoplegia
anti‐ganglioside Q1b immunoglobulin G antibody
areflexia
Ataxia
Immunoglobulin G
Immunoglobulins
Miller Fisher syndrome
Ophthalmoplegia
Patients
Reflexes
Vitamin deficiency
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Summary:We report the case of a 65‐year‐old woman who presented with acute complete bilateral ophthalmoplegia and ptosis. Deep tendon reflexes were normal and there were no signs of ataxia. On laboratory examination, the patient had vitamin B1 deficiency; however, symptoms did not improve after fursultiamine administration. Thereafter, it was found that the patient was seropositive for anti‐ganglioside Q1b immunoglobulin G antibody, and she was diagnosed with acute ophthalmoplegia and ptosis associated with anti‐ganglioside Q1b immunoglobulin G antibody. The patient's symptoms improved gradually without further treatment over the next several months. Ataxia and areflexia were not observed during the clinical course.
ISSN:2049-4173
2049-4173
DOI:10.1111/ncn3.12144