結核性胸膜炎患者における胸水中のBCG抗原量とAdenosine deaminase活性
酵素免疫測定法により結核性胸膜炎患者および非結核患者の胸水中におけるBCG抗原の検出について検討した. また, 胸水中のadenosine deaminase (ADA) 活性の測定も同時に試みた. 非結核患者34名と結核菌は分離されなかったものの臨床経過から結核性胸膜炎が疑われた2例から得られた胸水中のBCG抗原量は6ng/ml以下であった. 一方, 胸水から結核菌が分離された3例では18ng/ml以上のBCG抗原が検出された. 胸水中のADA活性値は結核性胸膜炎患者5例では平均84.4±35.4IU/l, 非結核患者で19.1±10.6IU/lであり, 結核性胸膜炎患者で有意 (p<...
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| Published in | 感染症学雑誌 Vol. 61; no. 6; pp. 662 - 667 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本感染症学会
01.06.1987
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| Online Access | Get full text |
| ISSN | 0387-5911 1884-569X |
| DOI | 10.11150/kansenshogakuzasshi1970.61.662 |
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| Abstract | 酵素免疫測定法により結核性胸膜炎患者および非結核患者の胸水中におけるBCG抗原の検出について検討した. また, 胸水中のadenosine deaminase (ADA) 活性の測定も同時に試みた. 非結核患者34名と結核菌は分離されなかったものの臨床経過から結核性胸膜炎が疑われた2例から得られた胸水中のBCG抗原量は6ng/ml以下であった. 一方, 胸水から結核菌が分離された3例では18ng/ml以上のBCG抗原が検出された. 胸水中のADA活性値は結核性胸膜炎患者5例では平均84.4±35.4IU/l, 非結核患者で19.1±10.6IU/lであり, 結核性胸膜炎患者で有意 (p<0.01) に高値を示した. 胸水中のADA活性の測定はBCG抗原の検出よりも迅速, 簡便で結核性胸膜炎の診断に有用と思われた. |
|---|---|
| AbstractList | 酵素免疫測定法により結核性胸膜炎患者および非結核患者の胸水中におけるBCG抗原の検出について検討した. また, 胸水中のadenosine deaminase (ADA) 活性の測定も同時に試みた. 非結核患者34名と結核菌は分離されなかったものの臨床経過から結核性胸膜炎が疑われた2例から得られた胸水中のBCG抗原量は6ng/ml以下であった. 一方, 胸水から結核菌が分離された3例では18ng/ml以上のBCG抗原が検出された. 胸水中のADA活性値は結核性胸膜炎患者5例では平均84.4±35.4IU/l, 非結核患者で19.1±10.6IU/lであり, 結核性胸膜炎患者で有意 (p<0.01) に高値を示した. 胸水中のADA活性の測定はBCG抗原の検出よりも迅速, 簡便で結核性胸膜炎の診断に有用と思われた. |
| Author | 松原, 藤継 吉田, 知孝 藤田, 信一 |
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| References | 10) Benjamin, R. G., Debanne, S. M., Ma, Y. & Daniel, T.M.: Evaluation of mycobacterial antigens in an enzyme-linked immunosorbent assay (ELISA) for the serodiagnosis of tuberculosis. J. Med. Microbiol., 18: 309-318, 1984. 13) Krambovitis, E., Mclllmurray, M. B., Lock, P. E., Hendrickse, W. & Holzel, H.: Rapid diagnosis of tuberculous meningitis by latex particle agglutination. Lancet, 11: 1229-1231, 1984. 4) Baig, M. M. E., Pettengell, K. E., Simjee, A.E., Sathar, M.A. & Vorster, B.J.: Diagnosis of tuberculosis by detection of myobacterial antigen in pleural effusions and ascites. S. Afr. Med. J., 69: 101-102, 1986. 11) Winters, W. D. & Cox, R. A.: Serodiagnosis of tuberculosis by radioimmunoassay. Am. Rev. Respir. Dis., 124: 582-585, 1981. 19) Piras, M. A. & Gakis, C.: Cerebrospinal fluid adenosine deaminase activity in tuberculous menigitis. Enzyme, 14: 311-317, 1973. 17) Fujita, S., Matubara, F. & Matsuda, T.: Enzyme-linked immkunosorbent assay measurement of fluctuations in antibody titer and antigenemia in cancer patients with and without candidiasis. J. Clin. Microbiol., 23: 568-575, 1986. 12) Straus, E. & Wu, N.: Radioimmunoassay of tuberculoprotein derived from Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U. S. A., 77: 4301-4304, 1980. 3) Sada, E., Ruiz-Palacios, G. M., Lopez-Vidal, Y. & De Leon, P. S.: Detection of mycobacterial antigens in cerebrospinal fluid of patients with tuberculous meningitis by enzyme-linked immunosorbent assay. Lancet, ii: 651-652, 1983. 14) Kadival, G. V., Samuel, A. M., Virdi, B. S., Kale, R. N. & Ganatra, R. D.: Radioimmunoassay of tuberculous antigen. Indian J. Med. Res., 75: 765-770, 1982. 1) Winkelman, M. & Pfitzer, P.: Blind pleural biopsy in combination with cytology of pleural effusions. Acta Cytol., 25: 373-376, 1981. 2) Sinha, P.K., Sinha, B. B. & Sinha, A. R. S.: Diagnosing tuberculous pleural effusion: Comparative sensitivity of mycobacterial culture, histopathology and adenosine deaminase activity. J. Assoc. Physicians India, 33: 644-645, 1985. 7) Yoshitake, S., Imagawa, M., Ishikawa, E., Nitsu, Y., Urushizaki, I., Nishiura, ER, Kanazawa, R., Kurosaki, H., Tachibana, S., Nakazawa, N. & Ogawa, H.: Mild and efficient conjugation of rabbit fab' and horseradish peroxidase using a maleimide compound and its use for enzyme immunoassay. J. Biochem., 92: 1413-1424, 1982. 5) Piras, M.A., Gakis, C. & Budroni, M. & Anderoni, G.: Adenosine deaminase activity in pleural effusions: An aid to differential diagnosis. Br. Med. 2: 1751-1752. 1978. 6) 森隆司郎, 石原陽子, 北村諭, 小坂徳梅: 胸水中adenosine deaminase (ADA) 活性値の測定-癌性胸膜炎と結核性胸膜炎を中心として. 日胸疾会誌, 19: 35-39, 1981. 16) Doskeland, S. O. & Berdal, B. P.: Bacterial antigen detection in body fluids: Methods for rapid antigen concentration and reduction of nonspecific reactions. J. Clin. Microbiol., 11: 380-384, 1980. 15) Krambovitis, E., Harris, M. & Hughes, D.: Improved serodiagnosis of tuberculosis using two assay test. J. Clin. Pathol., 39: 779-785, 1986. 18) Parkman, R., Gelfand, E.W., Rosen, F.S., Sanderson, A. & Hirschhorn, R.: Severe combined immunodeficiency and adenosine deaminase deficiency. N. Eng. J, Med., 292: 714-719, 1975. 9) 沢村献児, 長岡豊, 飯岡壮吾, 中村健二, 森隆, 橋本聡一, 井内敬二, 中元賢武, 李龍彦, 前田元: 最近の慢性膿胸765例の治療成績. 国療膿胸研究班の集計 (その1). 日胸, 41: 408-415, 1982. 8) Martensson, G., Pettersson, K. & Thiringer, G.: Differentiation between malignant and nonmalignant pleural effusion. Eur. J. Respir. Dis., 67: 326-334, 1985. |
| References_xml | – reference: 1) Winkelman, M. & Pfitzer, P.: Blind pleural biopsy in combination with cytology of pleural effusions. Acta Cytol., 25: 373-376, 1981. – reference: 18) Parkman, R., Gelfand, E.W., Rosen, F.S., Sanderson, A. & Hirschhorn, R.: Severe combined immunodeficiency and adenosine deaminase deficiency. N. Eng. J, Med., 292: 714-719, 1975. – reference: 4) Baig, M. M. E., Pettengell, K. E., Simjee, A.E., Sathar, M.A. & Vorster, B.J.: Diagnosis of tuberculosis by detection of myobacterial antigen in pleural effusions and ascites. S. Afr. Med. J., 69: 101-102, 1986. – reference: 9) 沢村献児, 長岡豊, 飯岡壮吾, 中村健二, 森隆, 橋本聡一, 井内敬二, 中元賢武, 李龍彦, 前田元: 最近の慢性膿胸765例の治療成績. 国療膿胸研究班の集計 (その1). 日胸, 41: 408-415, 1982. – reference: 12) Straus, E. & Wu, N.: Radioimmunoassay of tuberculoprotein derived from Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U. S. A., 77: 4301-4304, 1980. – reference: 13) Krambovitis, E., Mclllmurray, M. B., Lock, P. E., Hendrickse, W. & Holzel, H.: Rapid diagnosis of tuberculous meningitis by latex particle agglutination. Lancet, 11: 1229-1231, 1984. – reference: 7) Yoshitake, S., Imagawa, M., Ishikawa, E., Nitsu, Y., Urushizaki, I., Nishiura, ER, Kanazawa, R., Kurosaki, H., Tachibana, S., Nakazawa, N. & Ogawa, H.: Mild and efficient conjugation of rabbit fab' and horseradish peroxidase using a maleimide compound and its use for enzyme immunoassay. J. Biochem., 92: 1413-1424, 1982. – reference: 19) Piras, M. A. & Gakis, C.: Cerebrospinal fluid adenosine deaminase activity in tuberculous menigitis. Enzyme, 14: 311-317, 1973. – reference: 5) Piras, M.A., Gakis, C. & Budroni, M. & Anderoni, G.: Adenosine deaminase activity in pleural effusions: An aid to differential diagnosis. Br. Med. 2: 1751-1752. 1978. – reference: 8) Martensson, G., Pettersson, K. & Thiringer, G.: Differentiation between malignant and nonmalignant pleural effusion. Eur. J. Respir. Dis., 67: 326-334, 1985. – reference: 14) Kadival, G. V., Samuel, A. M., Virdi, B. S., Kale, R. N. & Ganatra, R. D.: Radioimmunoassay of tuberculous antigen. Indian J. Med. Res., 75: 765-770, 1982. – reference: 16) Doskeland, S. O. & Berdal, B. P.: Bacterial antigen detection in body fluids: Methods for rapid antigen concentration and reduction of nonspecific reactions. J. Clin. Microbiol., 11: 380-384, 1980. – reference: 11) Winters, W. D. & Cox, R. A.: Serodiagnosis of tuberculosis by radioimmunoassay. Am. Rev. Respir. Dis., 124: 582-585, 1981. – reference: 3) Sada, E., Ruiz-Palacios, G. M., Lopez-Vidal, Y. & De Leon, P. S.: Detection of mycobacterial antigens in cerebrospinal fluid of patients with tuberculous meningitis by enzyme-linked immunosorbent assay. Lancet, ii: 651-652, 1983. – reference: 6) 森隆司郎, 石原陽子, 北村諭, 小坂徳梅: 胸水中adenosine deaminase (ADA) 活性値の測定-癌性胸膜炎と結核性胸膜炎を中心として. 日胸疾会誌, 19: 35-39, 1981. – reference: 10) Benjamin, R. G., Debanne, S. M., Ma, Y. & Daniel, T.M.: Evaluation of mycobacterial antigens in an enzyme-linked immunosorbent assay (ELISA) for the serodiagnosis of tuberculosis. J. Med. Microbiol., 18: 309-318, 1984. – reference: 17) Fujita, S., Matubara, F. & Matsuda, T.: Enzyme-linked immkunosorbent assay measurement of fluctuations in antibody titer and antigenemia in cancer patients with and without candidiasis. J. Clin. Microbiol., 23: 568-575, 1986. – reference: 2) Sinha, P.K., Sinha, B. B. & Sinha, A. R. S.: Diagnosing tuberculous pleural effusion: Comparative sensitivity of mycobacterial culture, histopathology and adenosine deaminase activity. J. Assoc. Physicians India, 33: 644-645, 1985. – reference: 15) Krambovitis, E., Harris, M. & Hughes, D.: Improved serodiagnosis of tuberculosis using two assay test. J. Clin. Pathol., 39: 779-785, 1986. |
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| Snippet | 酵素免疫測定法により結核性胸膜炎患者および非結核患者の胸水中におけるBCG抗原の検出について検討した. また, 胸水中のadenosine deaminase (ADA) 活性の測定も同時に試みた.... |
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| Title | 結核性胸膜炎患者における胸水中のBCG抗原量とAdenosine deaminase活性 |
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