THE EFFECT OF ANTITUBERCULOUS SUBSTANCES ON THE AUTONOMIC NERVOUS FUNCTIONS II. STUDIES ON THE PHARMACO-DYNAMIC FUNCTIONS OF PARA-AMINOSALICYLIC ACID AND ISONICOTINIC ACID HYDRAZIDE

• Published in: Kekkaku Vol. 29; no. 11; pp. 458 - 460
• Main Authors: YAMASAKI, MASAYASU, DAIMON, SYUJI
• Format: Journal Article
• Language: English; Japanese
• Published: Japan JAPANESE SOCIETY FOR TUBERCULOSIS 01.11.1954
• Subjects: Aminosalicylic Acid - pharmacology; Autonomic Nervous System - drug effects; Isoniazid; Niacin; Nicotinic Acids - pharmacology; Old Medline; PARA-AMINOSALICYLIC ACID/effects; NICOTINIC ACID ISOMERS/effects; AUTONOMIC NERVOUS SYSTEM/effect of drugs on
• ISSN: 0022-9776; 1884-2410
• DOI: 10.11400/kekkaku1923.29.458

Our previous study demonstrated the effect of streptomycin (STM) on the autonomic nervous functions and we ascertained that STM promoted the function of the parasympathetic nervous system. In this report, the experiments on the action of para-aminosalicylic acid (PAS) and isonicotinic acid hydrazid (INAH) on the autonomic nervous functions were performed as in the case of STM (1st report). The results of these experiments show that PAS and INAH give little effect on the intestinal tracts of guinea pigs and on the blood pressure of rabbits, and that these drugs neither promote the action of acetylcholin, nor inhibit the action of epinephrine. Furthermore, PAS and INAH have no inhibitory effect upon cholinesterase in the blood serum. But when rabbits are administered with a large dose of INAH, it produces a convulsion. An excessive dose of INAH, therefore, may stimulate the sympathetic nervous system. From these facts, it is conceivable that PAS and INAH, unlike STM, have little effect directly on the autonomic nervous system of the living body.