Development and clinical application of ICG clearance meter

We have developed a finger-piece method that can indicates an accurate concentration of ICG based on the two wavelength spectrophotometry. Seventy-eight subjects were evaluated by this new method. The ICG clearance curve obtained from ICG clearance meter showed a rapid increase 20 or 40 seconds afte...

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Published inNippon Shōkakibyō Gakkai zasshi Vol. 86; no. 11; p. 2532
Main Authors Ishigami, Y, Miyoshi, E, Masuzawa, M, Katou, M, Terada, A, Okuyama, T, Tamura, K, Hatakenaka, M, Morita, H, Funahashi, S
Format Journal Article
LanguageJapanese
Published Japan 1989
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
Female
Humans
Indocyanine Green - pharmacokinetics
Liver Diseases - diagnosis
Liver Function Tests - instrumentation
Liver Function Tests - methods
Male
Metabolic Clearance Rate
Middle Aged
Spectrophotometry
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Summary:We have developed a finger-piece method that can indicates an accurate concentration of ICG based on the two wavelength spectrophotometry. Seventy-eight subjects were evaluated by this new method. The ICG clearance curve obtained from ICG clearance meter showed a rapid increase 20 or 40 seconds after the bolus injection. The curve decreased gradually, and increased again at 60 or 70 seconds. Plasma disappearance rate (PDR) by this method (XK ICG) was calculated by the at least square method from 600 data obtained from 5 to 15 minutes after the injection. There was a significant correlation between conventional PDR (KICG) and new method (XK ICG) also. We assume that this method have a possibility to discover new aspect of pharmacokinetics of ICG.
ISSN:0446-6586
DOI:10.11405/nisshoshi1964.86.2532