103Ru for Tumor Scanning A Comparative Study on Tissue Distributions of 103Ru-chloride and 103Ru-citrate in Tumor-Bearing Animals

Biological distribution of 103Ru in mice bearing Ehlrich's solid tumor and rats bearing AH 130 solid tumor were studied with two compounds of 103Ru, the chloride and citrate. The radioactivity of 103Ru-chloride showed slower excretion and higher tumor concentration than that of citrate. The tum...

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Published inRADIOISOTOPES Vol. 27; no. 5; pp. 245 - 250
Main Authors MIZUKAWA, Kiichiro, YAMAMOTO, Goki, TAMAI, Toyosato, TANABE, Masatada, YAMAMOTO, Michio
Format Journal Article
LanguageJapanese
Published Japan Japan Radioisotope Association 01.05.1978
Subjects
Animals
Carcinoma, Ehrlich Tumor - diagnostic imaging
Carcinoma, Ehrlich Tumor - metabolism
Chlorides - metabolism
Citrates - metabolism
Kidney - metabolism
Liver - metabolism
Lung - metabolism
Male
Mice
Muscles - metabolism
Radioisotopes - metabolism
Radionuclide Imaging
Ruthenium - metabolism
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Summary:Biological distribution of 103Ru in mice bearing Ehlrich's solid tumor and rats bearing AH 130 solid tumor were studied with two compounds of 103Ru, the chloride and citrate. The radioactivity of 103Ru-chloride showed slower excretion and higher tumor concentration than that of citrate. The tumor-to-muscle ratios of chloride were always higher, but the tumor-to-blood ratios were always lower than those of citrate.No significant difference was founds between 103Ru-chloride and citrate as tumor scanning agents.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0033-8303
1884-4111
DOI:10.3769/radioisotopes.27.5_245