CLINICAL EVALUATION OF HAPA-B IN COMPLICATED URINARY TRACT INFECTION

• Published in: CHEMOTHERAPY Vol. 33; no. Supplement5; pp. 592 - 598
• Main Authors: YAMAMOTO, TOSHIHIRO, HIRAYAMA, HIDEO, YAMASAKI, KOZO, IKEGAMI, KEIICHI, TERASAKI, HIROSHI, SAKIYAMA, HIROSHI, NABEKURA, YASUFUMI, UENO, FUMIMARO, NISHI, MASAO, TOKI, NAOTAKA, SHIMOMURA, TAKAFUMI, MURAKAMI, HAGEMU
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1985
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.33.Supplement5_592

HAPA-B, a new aminoglycoside antibiotic, was intramuscularly administrated to 18patients with complicated urinary tract infection at the dose of 400 mg per day in two divideddoses for 5 to 9 days. 1) On 7 cases that satisfied the “Criteria for Evaluation of Drug Efficacy in UTI” Overall clinical efficacy: Excellent in one case, moderate in 4 cases and poor in 2 cases. The overall effectiveness rate was 71.4%. Overall clinical efficacy classified by type of infection: The effectiveness rates were 100% in the single infection group, 100% in the catheter indwelt group and 33.3% in the group without catheter. Bacteriological response: The disappearance rate was 78.6% of 14 strains. 2) On all cases Overall clinical efficacy: Excellent in 5 cases, good in 10 cases and fair in 3 cases. The overall effectiveness rate was 83.3%. Bacteriological response: The disappearance rate was 78.8% of 33 strains. 3) Side effects and abnormal laboratory findings: There were no obvious side effects other than temporal elevations of GPT in one case. 4) The present results show that HAPA-B is considered to be a useful antibiotic in the treatment of complicated urinary tract infection.