BASIC AND CLINICAL STUDIES ON RU 28965 AGAINST OTORHINOLARYNGOLOGICAL INFECTIONS

We performed basic and clinical studies on RU 28965 in infections in the otorhinolaryngological field. The results obtained were as follows: 1. The mean concentration of RU 28965 after oral administration of a single 150 mg tablet was 4.62μg/giml in serum, 1.81μg/g in tonsil, and 2.38μg/g in sinus m...

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Published inCHEMOTHERAPY Vol. 36; no. Supplement4; pp. 514 - 521
Main Authors MATSUZAKI, TSUTOMU, FUKUDA, KATSUNORI, SHIMA, TETSUYA, ITO, KAZUNORI, UCHIZONO, AKIHIRO, IMAMURA, YOKO, USHIKAI, MASATO, OHYAMA, MASARU, OGAWA, KEI, OHHORI, YASUICHI, OGAWA, KAZUAKI
Format Journal Article
LanguageEnglish
Japanese
Published Japanese Society of Chemotherapy 1988
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Summary:We performed basic and clinical studies on RU 28965 in infections in the otorhinolaryngological field. The results obtained were as follows: 1. The mean concentration of RU 28965 after oral administration of a single 150 mg tablet was 4.62μg/giml in serum, 1.81μg/g in tonsil, and 2.38μg/g in sinus mucous membrane. 2. The efficacy rates were 80.0% for acute otitis media, 36.4% for chronic otitis media, 100% for acute sinusitis and 80.0% for acute tonsillitis. 3. No clinical adverse effects or abnormal laboratory findings were found.
ISSN:0009-3165
1884-5894
DOI:10.11250/chemotherapy1953.36.Supplement4_514