STUDIES ON AZTHREONAM IN THE FIELD OF OPHTHALMOLOGY
Fundamental and clinical studies on Azthreonam, a new antibiotic, were carried out in the field of ophthalmology and the following results were obtained. 1. The MIC of Azthreonam against E. cloacae and K. pneumoniae from infectious eyedisease ranged from ≤0.2μg/ml-1.2.5μg/ml and ≤0.2μg/ml-100μg/ml,...
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| Published in | CHEMOTHERAPY Vol. 33; no. Supplement1; pp. 910 - 913 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
Japanese Society of Chemotherapy
01.01.1985
公益社団法人 日本化学療法学会 |
| Online Access | Get full text |
| ISSN | 0009-3165 1884-5894 |
| DOI | 10.11250/chemotherapy1953.33.Supplement1_910 |
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| Abstract | Fundamental and clinical studies on Azthreonam, a new antibiotic, were carried out in the field of ophthalmology and the following results were obtained. 1. The MIC of Azthreonam against E. cloacae and K. pneumoniae from infectious eyedisease ranged from ≤0.2μg/ml-1.2.5μg/ml and ≤0.2μg/ml-100μg/ml, and the MIC of Azthreonam against S. aureus and S. epidermidis was 100μg/ml->100μg/ml. 2. Low concentrations of Azthreonam in tear and aqueous humor were detected afterintravenous administration of 50mg/kg Azthreonam in rabbits. 3. Serum concentrations of Azthreonam in rabbits peaked 30 minutes after intravenous administration of 50mg/kg. 4. Azthreonam was administered 1g d. i. 4 patients with eye infections including 2 cases with lid phlegmone, 1 case with corneal infection and 1 case with acute dacryocystitis. The effectiveness rate obtain was 100% in all cases. |
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| AbstractList | Fundamental and clinical studies on Azthreonam, a new antibiotic, were carried out in the field of ophthalmology and the following results were obtained. 1. The MIC of Azthreonam against E. cloacae and K. pneumoniae from infectious eyedisease ranged from ≤0.2μg/ml-1.2.5μg/ml and ≤0.2μg/ml-100μg/ml, and the MIC of Azthreonam against S. aureus and S. epidermidis was 100μg/ml->100μg/ml. 2. Low concentrations of Azthreonam in tear and aqueous humor were detected afterintravenous administration of 50mg/kg Azthreonam in rabbits. 3. Serum concentrations of Azthreonam in rabbits peaked 30 minutes after intravenous administration of 50mg/kg. 4. Azthreonam was administered 1g d. i. 4 patients with eye infections including 2 cases with lid phlegmone, 1 case with corneal infection and 1 case with acute dacryocystitis. The effectiveness rate obtain was 100% in all cases. Fundamental and clinical studies on Azthreonam, a new antibiotic, were carried out in the field of ophthalmology and the following results were obtained.1. The MIC of Azthreonam against E. cloacae and K. pneumoniae from infectious eyedisease ranged from ≤0.2μg/ml-1.2.5μg/ml and ≤0.2μg/ml-100μg/ml, and the MIC of Azthreonam against S. aureus and S. epidermidis was 100μg/ml->100μg/ml.2. Low concentrations of Azthreonam in tear and aqueous humor were detected afterintravenous administration of 50mg/kg Azthreonam in rabbits.3. Serum concentrations of Azthreonam in rabbits peaked 30 minutes after intravenous administration of 50mg/kg.4. Azthreonam was administered 1g d. i. 4 patients with eye infections including 2 cases with lid phlegmone, 1 case with corneal infection and 1 case with acute dacryocystitis. The effectiveness rate obtain was 100% in all cases. Azthreonamは単環系β-ラクタム抗生物質でモノバクタムと呼ばれる新しい薬剤である。その抗菌力はグラム陽性菌よりグラム陰性菌に対し強い抗菌力を有し, 本剤は全化学合成品であるためアレルギー反応の発現はほとんど認められないといわれている。今回, 眼科領域に関して検討した。まず抗菌力であるが臨床分離株に対してやはりS. aureus, S. epfdermidisのグラム陽性菌に対する抗菌力は弱く, グラム陰性菌であるE. cloacae, K. pneumonlaeに対する抗菌力は強かった。また本剤の体液内移行をみるため家兎に50mg/kgを静注し, その血清内, 房水内, 涙液内移行をみると, 血清内濃度は投与後2時間まで高濃度に移行が認められたが, 房水内および涙液内濃度は低く持続も短く, 涙液内移行は2時間まで, 房水内移行は4時間までしか認められなかった。一方, 本剤の家兎眼における1mg/0.1ml, 5mg/0.1mlの結膜下注射による房水内濃度をみると, 極めて高い濃度が移行することが認められた。これらの基礎的検討より原則的に本剤の眼感染症における適応は, 血清内濃度が治療に大きな役割を占める眼瞼, 涙器, 眼窩などにおける感染症と思われた。また, 角膜感染症には房水内移行からみる限り結膜下注射による方法が効果的と思われた。本剤の臨床的効果をみると, 1日1回1gを5%glucose 250mlに溶解して60分にて点滴し, 眼瞼蜂窩織炎2例, 急性涙嚢炎1例, 角膜感染症1例, 計4例を対象として投与したが, いずれも3日間以内の投与にて効果が認められ, 自覚的に何らの忌むべき副作用もなかった。 |
| Author | HATANO, HIROSHI BABA, YASUHIKO ONISHI, HITOMI |
| Author_FL | 大西 人実 葉田野 博 馬場 安彦 |
| Author_FL_xml | – sequence: 1 fullname: 葉田野 博 – sequence: 2 fullname: 馬場 安彦 – sequence: 3 fullname: 大西 人実 |
| Author_xml | – sequence: 1 fullname: HATANO, HIROSHI organization: Department of Ophthalmology Iwaki Municipal Joban Hospital – sequence: 1 fullname: BABA, YASUHIKO organization: Department of Ophthalmology Iwaki Municipal Joban Hospital – sequence: 1 fullname: ONISHI, HITOMI organization: Department of Ophthalmology Iwaki Municipal Joban Hospital |
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| References | 1) 第30回日本化学療法学会東日本支部総会, 新薬シンポジウム, Azthreonam (SQ 26, 776), 東京, 1983 |
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| Title | STUDIES ON AZTHREONAM IN THE FIELD OF OPHTHALMOLOGY |
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