STUDIES ON AZTHREONAM IN THE FIELD OF OPHTHALMOLOGY

Fundamental and clinical studies on Azthreonam, a new antibiotic, were carried out in the field of ophthalmology and the following results were obtained. 1. The MIC of Azthreonam against E. cloacae and K. pneumoniae from infectious eyedisease ranged from ≤0.2μg/ml-1.2.5μg/ml and ≤0.2μg/ml-100μg/ml,...

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Published inCHEMOTHERAPY Vol. 33; no. Supplement1; pp. 910 - 913
Main Authors HATANO, HIROSHI, BABA, YASUHIKO, ONISHI, HITOMI
Format Journal Article
LanguageEnglish
Japanese
Published Japanese Society of Chemotherapy 01.01.1985
公益社団法人 日本化学療法学会
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ISSN0009-3165
1884-5894
DOI10.11250/chemotherapy1953.33.Supplement1_910

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Summary:Fundamental and clinical studies on Azthreonam, a new antibiotic, were carried out in the field of ophthalmology and the following results were obtained. 1. The MIC of Azthreonam against E. cloacae and K. pneumoniae from infectious eyedisease ranged from ≤0.2μg/ml-1.2.5μg/ml and ≤0.2μg/ml-100μg/ml, and the MIC of Azthreonam against S. aureus and S. epidermidis was 100μg/ml->100μg/ml. 2. Low concentrations of Azthreonam in tear and aqueous humor were detected afterintravenous administration of 50mg/kg Azthreonam in rabbits. 3. Serum concentrations of Azthreonam in rabbits peaked 30 minutes after intravenous administration of 50mg/kg. 4. Azthreonam was administered 1g d. i. 4 patients with eye infections including 2 cases with lid phlegmone, 1 case with corneal infection and 1 case with acute dacryocystitis. The effectiveness rate obtain was 100% in all cases.
ISSN:0009-3165
1884-5894
DOI:10.11250/chemotherapy1953.33.Supplement1_910