Phototoxicity study of garenoxacin in guinea pigs

• Published in: Japanese Journal of Chemotherapy Vol. 55; no. Supplement1; pp. 75 - 77
• Main Authors: Sanzen, Takahiro, Kito, Nobuko, Kiyooka, Masashi, Todo, Yozo
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 01.10.2007; 公益社団法人 日本化学療法学会
• Subjects: des-fluoro -quinolone; garenoxacin; phototoxicity
• ISSN: 1340-7007; 1884-5886
• DOI: 10.11250/chemotherapy1995.55.Supplement1_75

The phototoxicity of Garenoxacin mesilate hydrate (GRNX) in guinea pigs was studied. In this study, the phototoxic potential of GRNX was compared to that of ciprofloxacin hydrochloride (CPFX) and levofloxacin (LVFX) as comparative articles. Animals were administered a single dose intravenously with each article at the dose level of 100mg/kg as free base, and irradiated with ultraviolet A (UVA) of about 10 J/cm2 for about 30 minutes starting at 10 minutes after administration. The skin reactions of these animals were observed macroscopically at 24 and 48 hours after irradiation. A control group was administered physiological saline. GRNX showed no skin reaction after 24 and 48 hours. CPFX showed moderate skin reaction in all animals both after 24 and 48 hours. LVFX showed a slight skin reaction in one of six animals after 24 hours, but the skin reaction disappeared after 48 hours. Plasma concentration of GRNX during irradiation (10 to 40 minutes after administration) with UVA was comparable to that of LVFX, and was higher than that of CPFX. As mentioned above, we consider that the phototoxic potential of GRNX is weaker than that of CPFX and LVFX.