In vitro and in vivo antibacterial activity of tazobactam/piperacillin

• Published in: CHEMOTHERAPY Vol. 42; no. Supplement2; pp. 164 - 177
• Main Authors: Minami, Shinzaburo, Yamada, Hisashi, Okamoto, Seiki, Narita, Hirokazu, Maehana, Junko, Horii, Taeko, Myohara, Yuki, Ogake, Naoko, Araki, Harumi, Fujimaki, Kazuo, Matsumura, Naoki, Kitayama, Rieko, Watanabe, Yasuo, Yasuda, Takashi
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1994; 公益社団法人 日本化学療法学会
• Subjects: TAZ/PIPC; tazobactam; tazobactam/piperacillin; YP-14; β-lactamase阻害活性; 抗菌活性
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.42.Supplement2_164

We studied the β-lactamase inhibitory activity of tazobactam (TAZ) and the in vitro and in vivo antibacterial activity of tazobactam/piperacillin (TAZ/PIPC). The following results were obtained. 1) TAZ inhibited various β-lactamases more effectively than sulbactam. A progressiv inhibition of TAZ against cephalosporinases was observed. 2) TAZ/PIPC exhibited a broad spectrum of antibacterial activity and potent activity against aerobic and anaerobic bacteria. 3) TAZ enhanced the activity of PIPC against PIPC-resistant bacteria such as Staphylococcus aureus (methicillin-susceptible), Staphylococcus epidermidis (methicillin-susceptible), Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Haemophilus influenzae, Moraxella catarrhalis and Bacteroides fragilis, and TAZ/PIPC was equally or more active than sulbactam/cefoperazone (SBT/CPZ), cefotiam and ceftazidime (CAZ) against P. aeruginosa, H. influenzae, M catarrhalis and B. fragilis resistant to PIPC. 4) The inducer activity of TAZ/PIPC for β-lactamase production was as low as that of PIPC. 5) TAZ/PIPC was more active than PIPC against rat pouch mixed infection caused by E. coli and penicillinase-producing S. epidermidis, rat intrauterine infection and mouse urinary tract infection caused by PIPC-resistant E. coli. TAZ/PIPC was more active than SBT/CPZ against rat pouch infection caused by P. aeruginosa highly resistant to CAZ.