BASIC AND CLINICAL STUDIES ON CEFPIROME IN THE SURGICAL FIELD

• Published in: CHEMOTHERAPY Vol. 39; no. Supplement1; pp. 367 - 378
• Main Authors: YAMADA, YOSHINARI, ISOBE, YOH, SAITO, TOSHIAKI
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1991
• Subjects: Cefpirome
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.39.Supplement1_367

We evaluated the stability of cefpirome (CPR) in human bile in 15 cases. The bile was prepared at 100μ/ml of CPR, then sequential residual activity was calculated at 20°C, 4°C and -20°C for pH value and β-lactamase activity. It was stable at -20°C until 24 h, but remarkable inactivation was observed at 20°C -8h, and in the two cases with β-lactamase activity and a pH value of more than 8.40, the most remarkable inactivation was observed. Penetration of CPR into exudate after radical mastectomy was calculated in four cases. A peak concentration of 20.5-76.6μg/ml was achieved after 2-4 h with a 1 g i. v. dose of CPR. CPR therapy was basically and clinically evaluated in 10 patients: 5 with acute cholecystitis, 2 with abscess, 1 with phlegmon, 1 with intraabdominal abscess and 1 with RLQ abdominal pain of unknown origin.(This last case was excluded from evaluation). Clinical response was good (including one excellent) in all 5 cases of cholecystitis and in both cases of abscess and phlegmon, but response was poor in the case of intraabdominal abscess. As to adverse effects, mild and transient elevation of GPT was observed.