Concentration of SY5555 in tissues and clinical efficacy in otorhinolaryngology

• Published in: CHEMOTHERAPY Vol. 42; no. Supplement1; pp. 612 - 617
• Main Authors: Harada, Yasuo, Suzuki, Mamoru, Hirakawa, Katsuhiro, Nakata, Shofu, Omura, Ryou, Yajin, Kouji, Noda, Masuhiro, Takebayashi, Shubun, Tagashira, Nobuharu, Kobayashi, Yuko
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1994
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.42.Supplement1_612

SY5555, a new penem antibiotic, was investigated in otorhinolaryngological infections. Concentrations in the tonsil, nasal polyp and mucosa of maxillary sinus were determined by bioassay method after oral administration of 200 mg of SY5555. The concentration of SY5555 was 0.82μg/ml in plasma and less than 0.03μg/g in the tonsil 60 min after administration. Concentrations in the nasal polyp and maxillary sinus mucosa were 0.05μg/g and 0.10μg/g 120 min after dosing, respectively. SY5555 was administered to 33 patients with otorhinolaryngological infections. The drug was efficacious in 19 of 25 evaluable caces. Side effects were observed in two cases. Nausea and stomach discomfort were observed in one, and vertigo, feeling of warmth and eye pain in the other. Abnormal laboratory findings were observed in two cases, but none of the abnormal fluctuations was serious or presented any particular clinical problems.