CLINICAL STUDY ON MEROPENEM

• Published in: CHEMOTHERAPY Vol. 40; no. Supplement1; pp. 768 - 772
• Main Authors: Takebe, Kazuo, Osonoi, Takeshi, Kuroda, Yasuhisa, Saito, Miyoko, Shimada, Takenobu, Tamura, Toyokazu, Hirota, Norihiko, Tanada, Atsuko, Takada, Hirohito, Masuda, Mitsuo, Murakami, Seiichi, Shirato, Hazime
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1992
• Subjects: Meropenem
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.40.Supplement1_768

We evaluated the clinical efficacy and safety of meropenem, a new carbapenem antibiotic, at a dose of 0.5-1.0 g twice a day for 4-17 days in 16 patients with respiratory tract infections, including 14 cases of pneumonia, one of acute exacerbation of chronic bronchitis and one of bronchial asthma with infection. Clinical efficacy was excellent in 5 patients, good in 7, fair in one, poor in 2 and unknown in one. The efficacy rate was 80%. Side effects were observed in 2 patients: one with headache and the other with slight rash. Three patients showed the following abnormal laboratory findings: decreased WBC in one case, elevation of S-GOT and S-GPT in one and elevation of NAG and β2-microglobulin in one.