Bacteriological and clinical studies on cefozopran for surgical application

• Published in: CHEMOTHERAPY Vol. 41; no. Supplement4; pp. 327 - 335
• Main Authors: Tanaka, Hidekazu, Iwai, Shigetomi, Sato, Takashi, Kunimatsu, Masahiko, Furuhata, Hisashi, Kato, Koumei, Izumi, Masataka, Chishima, Yoshiaki, Arai, Naoyuki, Sato, Fumii, Kazawa, Tamae, Cho, Enshun, Masuda, Hideki, Fujii, Masashi, Tanaka, Takashi
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1993
• Subjects: cefozopran
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.41.Supplement4_327

Bacteriological and clinical studies were carried out on cefozopran (CZOP). Antibacterial activities of CZOP against clinical isolates were studied in comparison with ampicillin, piperacillin, aspoxicillin, cefazolin, cefuroxime, cefoperazone, cefotiam, cefotaxime, ceftizoxime, cefpiramide, ceftazidime, ceftriaxone, cefuzonam, cefoxitin, cefmetazole, cefotetan, cefbuperazone, latamoxef, imipenem, tobramycin, amikacin and minocycline. Antibacterial activities of CZOP were studied against clinical isolates of gram negtive rods such as E.coli, K. pneumoniae, E. dome and P. aeruginosa. MICs (106/ml) of CZOP were ≤0.05-0.2μg/ml for E. coli, ≤0.05-3.13μg/ml for K.pneumoniae, ≤0.05->100μg/ml for E. cloacae and 0.2-12.5μg/ml for P. aeruginosa. MIC90 (106/ml) were 0.1μg/ml for E. coli, 1.56μg/ml for K.pneumoniae, 12.5μg/ml for E. cloacae and 12.5μg/ml for P. aeruginosa. Particularly, against P. aeruginosa, CZOP showed particularly strong activity compared with amikacin. After the intravenous administration of CZOP 1 g by 30 minutes, drip infusion, serum levels were 63.3-97.8μg/ml at the end of infusion and 4.5-9.5μg/ml at 5.5-6 hours after d.i.v. Bile levels were 0.6-22.1μg/ml at end of infusion and 3.4-7.2μg/ml at 5.5-6 hours after d.i.v. CZOP was administered intravenously by dripinfusion to 9 patients with various infections in the field of surgery. Clinical response was excellent in 4 cases and good in 5 cases. No side effects were noted.