CEFDINIR IN ELDERLY PATIENTS
We treated 17 elderly patients with bacterial infection with cefdinir (CFDN), a new oral cephem antibiotic, and investigated the drug's clinical efficacy and safety. The patients were: 2 with pneumonia, 8 with lower respiratory tract infection and 7 with urinary tract infection. The clinical ef...
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| Published in | CHEMOTHERAPY Vol. 37; no. Supplement2; pp. 496 - 503 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
Japanese Society of Chemotherapy
1989
公益社団法人 日本化学療法学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0009-3165 1884-5894 |
| DOI | 10.11250/chemotherapy1953.37.Supplement2_496 |
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| Abstract | We treated 17 elderly patients with bacterial infection with cefdinir (CFDN), a new oral cephem antibiotic, and investigated the drug's clinical efficacy and safety. The patients were: 2 with pneumonia, 8 with lower respiratory tract infection and 7 with urinary tract infection. The clinical effect was assessed as good in 10, fair in 3 and poor in 4 patients, with an efficacy rate of 59%. Bacteriological assessment produced the following results. Of two strains of Escherichia coil, one was eradicated, and the other decreased. Of four strains of Klebsiella pneumoniae, one was eradicated, one decreased, and the other two were replaced by E. coil and Pseudomonas aeruginosa respectively. One strain of Proteus mirabilis was replaced by Morganella morganii, while one strain of M.morganii and four strains of P. aeruginosa persisted. No adverse reactions were encountered. With regard to abnormal clinical laboratory findings, elevation of Al- P and eosinophilia was noted in one patient each, but subsided after the withdrawal of CFDN. As the subjects were elderly patients with underlying diseases, the above results suggest that CFDN is aneffective drug in the treatment of bacterial infection. |
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| AbstractList | We treated 17 elderly patients with bacterial infection with cefdinir (CFDN), a new oral cephem antibiotic, and investigated the drug's clinical efficacy and safety.The patients were: 2 with pneumonia, 8 with lower respiratory tract infection and 7 with urinary tract infection. The clinical effect was assessed as good in 10, fair in 3 and poor in 4 patients, with an efficacy rate of 59%. Bacteriological assessment produced the following results. Of two strains of Escherichia coil, one was eradicated, and the other decreased. Of four strains of Klebsiella pneumoniae, one was eradicated, one decreased, and the other two were replaced by E. coil and Pseudomonas aeruginosa respectively. One strain of Proteus mirabilis was replaced by Morganella morganii, while one strain of M.morganii and four strains of P. aeruginosa persisted. No adverse reactions were encountered. With regard to abnormal clinical laboratory findings, elevation of Al- P and eosinophilia was noted in one patient each, but subsided after the withdrawal of CFDN.As the subjects were elderly patients with underlying diseases, the above results suggest that CFDN is aneffective drug in the treatment of bacterial infection.
経口用セフェム系抗生物質であるcefdinir (CFDN) を高齢者における感染症17例に使用し, その臨床効果および副作用を検討した。疾患の内訳は肺炎2例, 下気道感染症8例, 尿路感染症7例である。その結果有効10例, やや有効3例, 無効4例で, 有効率59%であった。細菌学的効果では, Escherichia coli 2株中1株消失, 1株減少, Klbsiella pneumoniae 4株中1株消失, 1株減少, 2株はE.coliとPseudomoms aeruginosaにそれぞれ菌交代した。Proteus mimbilis 1株はMorganella morganiiに菌交代し, M.morganii 1株とP.aeruginosa 4株は不変であった。副作用は認められず, 臨床検査値の異常はAl-Pの上昇と好酸球の増加がそれぞれ1例ずつみられたが, いずれも本剤投与中止後軽快した。基礎疾患を有した高齢者を対象と快て, 以上の成績が得られ, CFDNの高齢者に対する有用性が示唆された。 We treated 17 elderly patients with bacterial infection with cefdinir (CFDN), a new oral cephem antibiotic, and investigated the drug's clinical efficacy and safety. The patients were: 2 with pneumonia, 8 with lower respiratory tract infection and 7 with urinary tract infection. The clinical effect was assessed as good in 10, fair in 3 and poor in 4 patients, with an efficacy rate of 59%. Bacteriological assessment produced the following results. Of two strains of Escherichia coil, one was eradicated, and the other decreased. Of four strains of Klebsiella pneumoniae, one was eradicated, one decreased, and the other two were replaced by E. coil and Pseudomonas aeruginosa respectively. One strain of Proteus mirabilis was replaced by Morganella morganii, while one strain of M.morganii and four strains of P. aeruginosa persisted. No adverse reactions were encountered. With regard to abnormal clinical laboratory findings, elevation of Al- P and eosinophilia was noted in one patient each, but subsided after the withdrawal of CFDN. As the subjects were elderly patients with underlying diseases, the above results suggest that CFDN is aneffective drug in the treatment of bacterial infection. |
| Author | YAMAMOTO, TOSHIYUKI ADACHI, SATORU SUZUKI, KANZO YAMAMOTO, KAZUHIDE |
| Author_FL | 鈴木 幹三 山本 俊幸 山本 和英 足立 暁 |
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| References | 3) 山本俊幸, 山本和英: 高齢者感染症の治療肺炎- 市内感染-. Geriat. Med. 26: 1444-1448, 1988 2) 山本俊幸: 高齢者肺炎の変貌 (その2). いずみ35 (2): 4-5, 1988 4) 山本和英, 鈴木幹三, 足立暁, 山本俊幸ほか: 経皮的気管内吸引法 (TTA) による高齢者肺炎の細菌学的検討. 日胸疾会誌26: 1170-1176, 1988 1) 第36回日本化学療法学会西日本支部総会, 新薬シンポジウム. FK482, 高知, 1988 5) 谷本普一, 蝶名林直彦, 鈴木幹三ほか: 肺炎. 内科47: 191-196, 1981 |
| References_xml | – reference: 2) 山本俊幸: 高齢者肺炎の変貌 (その2). いずみ35 (2): 4-5, 1988 – reference: 3) 山本俊幸, 山本和英: 高齢者感染症の治療肺炎- 市内感染-. Geriat. Med. 26: 1444-1448, 1988 – reference: 4) 山本和英, 鈴木幹三, 足立暁, 山本俊幸ほか: 経皮的気管内吸引法 (TTA) による高齢者肺炎の細菌学的検討. 日胸疾会誌26: 1170-1176, 1988 – reference: 5) 谷本普一, 蝶名林直彦, 鈴木幹三ほか: 肺炎. 内科47: 191-196, 1981 – reference: 1) 第36回日本化学療法学会西日本支部総会, 新薬シンポジウム. FK482, 高知, 1988 |
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| SubjectTerms | Cefdinir 呼吸器感染症 尿路感染症 臨床検討 高齢者 |
| Title | CEFDINIR IN ELDERLY PATIENTS |
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