CEFDINIR IN ELDERLY PATIENTS

• Published in: CHEMOTHERAPY Vol. 37; no. Supplement2; pp. 496 - 503
• Main Authors: YAMAMOTO, TOSHIYUKI, ADACHI, SATORU, SUZUKI, KANZO, YAMAMOTO, KAZUHIDE
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1989; 公益社団法人 日本化学療法学会
• Subjects: Cefdinir; 呼吸器感染症; 尿路感染症; 臨床検討; 高齢者
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.37.Supplement2_496

We treated 17 elderly patients with bacterial infection with cefdinir (CFDN), a new oral cephem antibiotic, and investigated the drug's clinical efficacy and safety. The patients were: 2 with pneumonia, 8 with lower respiratory tract infection and 7 with urinary tract infection. The clinical effect was assessed as good in 10, fair in 3 and poor in 4 patients, with an efficacy rate of 59%. Bacteriological assessment produced the following results. Of two strains of Escherichia coil, one was eradicated, and the other decreased. Of four strains of Klebsiella pneumoniae, one was eradicated, one decreased, and the other two were replaced by E. coil and Pseudomonas aeruginosa respectively. One strain of Proteus mirabilis was replaced by Morganella morganii, while one strain of M.morganii and four strains of P. aeruginosa persisted. No adverse reactions were encountered. With regard to abnormal clinical laboratory findings, elevation of Al- P and eosinophilia was noted in one patient each, but subsided after the withdrawal of CFDN. As the subjects were elderly patients with underlying diseases, the above results suggest that CFDN is aneffective drug in the treatment of bacterial infection.