CEFETAMET PIVOXIL IN URINARY TRACT INFECTION

• Published in: CHEMOTHERAPY Vol. 38; no. Supplement1; pp. 259 - 268
• Main Author: MATSUMOTO, TETSURO
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1990
• Subjects: Cefetamet pivoxil
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.38.Supplement1_259

Cefetamet pivoxil (CEMT-PI), a novel oral prodrug of cephalosporin type, was administered to 87 patients with uncomplicated or complicated urinary tract infection (UTI) and the following results were obtained. 1) After 2 days' treatment, of 8 patients with acute uncomplicated cystitis, excellent response was observed in 6 and moderate in 2, and after 5 days' treatment, excellent in 3, moderate in 2 and poor in one case. 2) In one case of acute uncomplicated pyelonephritis, moderate response was observed. 3) In complicated UTI cases without indwelling catheter, excellent response was observed in 12, moderate in 12 and poor in 19. The overall efficacy rate in complicated UTI was 56%. Bacteriologically, 45% of gram positive cocci were eliminated from urine after 5 days' treatment and 72% of gram negative rods. But 4 patients with indwelling catheter showed poor results. 4) Side effects were observed in 3 cases, namely, sleepiness, chill and abdominal fulness. There were six instances of abnormal laboratory findings related to liver function and blood cell counts.