BASIC AND CLINICAL STUDIES ON FLEROXACIN IN ORAL SURGERY
We performed experimental and clinical studies on fleroxacin, a new synthetic antimicrobial agent for oral use, in the field of oral surgery. 1. Fleroxacin, at 200mg, was administered to 135 patients, and the concentrations in blood of fleroxacin revealed 0.45-4.43μg/ml at 141-370 min, after adminis...
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| Published in | CHEMOTHERAPY Vol. 38; no. Supplement2; pp. 657 - 665 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
Japanese Society of Chemotherapy
1990
公益社団法人 日本化学療法学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0009-3165 1884-5894 |
| DOI | 10.11250/chemotherapy1953.38.Supplement2_657 |
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| Abstract | We performed experimental and clinical studies on fleroxacin, a new synthetic antimicrobial agent for oral use, in the field of oral surgery. 1. Fleroxacin, at 200mg, was administered to 135 patients, and the concentrations in blood of fleroxacin revealed 0.45-4.43μg/ml at 141-370 min, after administration in 55 subjects. 2. A clinical study was conducted in 53 patients with odontogenic infections. The efficacy rate, judged by comparative score evaluation, was 81.6%, while that by doctors was 73.5%. Causative bacteria were isolated from 17 patients. In five cases, side-effects (insomnia, dizziness, headache) occurred. Abnormal changes in laboratory findings were noted in two cases (mild increase in eosinophils and slight elevation of BUN, s-Cr). |
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| AbstractList | We performed experimental and clinical studies on fleroxacin, a new synthetic antimicrobial agent for oral use, in the field of oral surgery. 1. Fleroxacin, at 200mg, was administered to 135 patients, and the concentrations in blood of fleroxacin revealed 0.45-4.43μg/ml at 141-370 min, after administration in 55 subjects. 2. A clinical study was conducted in 53 patients with odontogenic infections. The efficacy rate, judged by comparative score evaluation, was 81.6%, while that by doctors was 73.5%. Causative bacteria were isolated from 17 patients. In five cases, side-effects (insomnia, dizziness, headache) occurred. Abnormal changes in laboratory findings were noted in two cases (mild increase in eosinophils and slight elevation of BUN, s-Cr). We performed experimental and clinical studies on fleroxacin, a new synthetic antimicrobial agent for oral use, in the field of oral surgery.1. Fleroxacin, at 200mg, was administered to 135 patients, and the concentrations in blood of fleroxacin revealed 0.45-4.43μg/ml at 141-370 min, after administration in 55 subjects.2. A clinical study was conducted in 53 patients with odontogenic infections. The efficacy rate, judged by comparative score evaluation, was 81.6%, while that by doctors was 73.5%. Causative bacteria were isolated from 17 patients. In five cases, side-effects (insomnia, dizziness, headache) occurred. Abnormal changes in laboratory findings were noted in two cases (mild increase in eosinophils and slight elevation of BUN, s-Cr). 新合成抗菌剤fleroxacinについて口腔外科領域への適応を基礎的, 臨床的に検討した。1.135例の抜歯予定患者を対象に, 本剤を200mg服用させ, 抜歯時に抜歯創部血液および唾液を採取し, その濃度を測定した。薬剤濃度は個人差はみられるが, 血中濃度で服用後141～370分の55例では, 0.45～4.43μg/mlの濃度が得られた。2.口腔外科領域の急性歯性感染症53例に本剤を使用した。臨床効果は点数判定では81.6%, 主治医判定では73.5%の有効率が得られた。副作用は5例に認められ, 主な副作用は不眠, めまいであった。臨床検査値異常は2例に認められ, 好酸球上昇1例, BUNおよび血清クレアチニンの上昇1例であった。 |
| Author | MORISHIMA, TAKASHI KANEKO, AKIHIRO SAKAMOTO, HARUO OTA, YOSHIHIDE MORIHANA, TAKEFUMI SASAKI, JIRO TOMITA, FUMISADA |
| Author_FL | 森島 丘 坂本 春生 森鼻 健史 佐々木 次郎 富田 文貞 金子 明寛 太田 嘉英 |
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| Author_xml | – sequence: 1 fullname: MORISHIMA, TAKASHI organization: Department of Oral Surgery, School of Medicine, Tokai University – sequence: 1 fullname: TOMITA, FUMISADA organization: Department of Dentistry and Oral Surgery, Ashikaga Red Cross Hospital – sequence: 1 fullname: SAKAMOTO, HARUO organization: Department of Oral Surgery, School of Medicine, Tokai University – sequence: 1 fullname: OTA, YOSHIHIDE organization: Department of Oral Surgery, School of Medicine, Tokai University – sequence: 1 fullname: SASAKI, JIRO organization: Department of Oral Surgery, School of Medicine, Tokai University – sequence: 1 fullname: MORIHANA, TAKEFUMI organization: Department of Dentistry and Oral Surgery, Ashikaga Red Cross Hospital – sequence: 1 fullname: KANEKO, AKIHIRO organization: Department of Oral Surgery, School of Medicine, Tokai University |
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| References | 1) AOYAMA H, INOUE M and MITSUHASHI S: In-vitro and in-vivo antibacterial activity of fleroxacin, a new fluorinated quinolone. J Antimicrob Chemother 22 (Suppl. D): 99-114, 1988 5) 森島丘, 他: 口腔外科領域におけるNY-198の基礎的・臨床的検討. Chemotherapy 36 (Suppl. 2): 1388-1401, 1988 2) HIRAI K, AOYAMA H, HOSAKA M, OOMORI Y, NIWATA Y, SUZUE S and IRIKURA T: In-vitro and In-vivo Antibacterial Activity of AM-833, a new Quinolone Derivative. Antimicrob Agent Chemother 29: 1059-1066, 1986 4) 高井宏, 久野吉雄, 道健一, 佐々木次郎: 歯性感染症に対する抗生物質の効果判定基準について. 歯薬療法1: 122-160, 1982 6) 森鼻健史, 坂本春生, 植松正孝, 山田善雄, 佐々木次郎, 椎木一雄: 口腔外科領域における DL-8280の基礎的・臨床的検討. Chemotherapy 32 (Suppl. 1): 1070-1083, 1984 3) 谷村弘, 副島林造: 第37回日本化学療法学会西日本支部総会, 新薬シンポジウム. AM-833 (Fleroxacin), 和歌山, 1989 7) 佐々木次郎, 関口登貴子, 植松正孝, 森島丘, 太田嘉英, 森鼻健史, 金子明寛, 富田文貞, 近 内寿勝: 口腔外科領域におけるT-3262の基礎的・臨床的検討. Chemotherapy 36 (Suppl. 9): 1488-1507, 1988 |
| References_xml | – reference: 4) 高井宏, 久野吉雄, 道健一, 佐々木次郎: 歯性感染症に対する抗生物質の効果判定基準について. 歯薬療法1: 122-160, 1982 – reference: 5) 森島丘, 他: 口腔外科領域におけるNY-198の基礎的・臨床的検討. Chemotherapy 36 (Suppl. 2): 1388-1401, 1988 – reference: 7) 佐々木次郎, 関口登貴子, 植松正孝, 森島丘, 太田嘉英, 森鼻健史, 金子明寛, 富田文貞, 近 内寿勝: 口腔外科領域におけるT-3262の基礎的・臨床的検討. Chemotherapy 36 (Suppl. 9): 1488-1507, 1988 – reference: 1) AOYAMA H, INOUE M and MITSUHASHI S: In-vitro and in-vivo antibacterial activity of fleroxacin, a new fluorinated quinolone. J Antimicrob Chemother 22 (Suppl. D): 99-114, 1988 – reference: 6) 森鼻健史, 坂本春生, 植松正孝, 山田善雄, 佐々木次郎, 椎木一雄: 口腔外科領域における DL-8280の基礎的・臨床的検討. Chemotherapy 32 (Suppl. 1): 1070-1083, 1984 – reference: 3) 谷村弘, 副島林造: 第37回日本化学療法学会西日本支部総会, 新薬シンポジウム. AM-833 (Fleroxacin), 和歌山, 1989 – reference: 2) HIRAI K, AOYAMA H, HOSAKA M, OOMORI Y, NIWATA Y, SUZUE S and IRIKURA T: In-vitro and In-vivo Antibacterial Activity of AM-833, a new Quinolone Derivative. Antimicrob Agent Chemother 29: 1059-1066, 1986 |
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| Title | BASIC AND CLINICAL STUDIES ON FLEROXACIN IN ORAL SURGERY |
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