BASIC AND CLINICAL STUDIES ON FLEROXACIN IN ORAL SURGERY

• Published in: CHEMOTHERAPY Vol. 38; no. Supplement2; pp. 657 - 665
• Main Authors: MORISHIMA, TAKASHI, TOMITA, FUMISADA, SAKAMOTO, HARUO, OTA, YOSHIHIDE, SASAKI, JIRO, MORIHANA, TAKEFUMI, KANEKO, AKIHIRO
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1990; 公益社団法人 日本化学療法学会
• Subjects: Fleroxacin; ニューキノロン系抗菌剤; 口腔外科領域感染症
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.38.Supplement2_657

We performed experimental and clinical studies on fleroxacin, a new synthetic antimicrobial agent for oral use, in the field of oral surgery. 1. Fleroxacin, at 200mg, was administered to 135 patients, and the concentrations in blood of fleroxacin revealed 0.45-4.43μg/ml at 141-370 min, after administration in 55 subjects. 2. A clinical study was conducted in 53 patients with odontogenic infections. The efficacy rate, judged by comparative score evaluation, was 81.6%, while that by doctors was 73.5%. Causative bacteria were isolated from 17 patients. In five cases, side-effects (insomnia, dizziness, headache) occurred. Abnormal changes in laboratory findings were noted in two cases (mild increase in eosinophils and slight elevation of BUN, s-Cr).