Clinical study of NM441 in complicated urinary tract infections

• Published in: Japanese Journal of Chemotherapy Vol. 44; no. Supplement1; pp. 692 - 694
• Main Authors: Maeda, Yoshitami, Yanagawa, Makoto, Tochigi, Hiromi, Kinbara, Hiroyuki, Kawamura, Juichi
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1996; 公益社団法人 日本化学療法学会
• Subjects: NM441; ニューキノロン薬; 尿路感染症
• ISSN: 1340-7007; 1884-5886
• DOI: 10.11250/chemotherapy1995.44.Supplement1_692

NM441, a new developed oral quinolone antibiotic, was administered to 6 patients with complicated urinary tract infections, and a clinical study was performed. The clinical response according to the doctor's evaluation was good in 4 cass and poor in 2 of 6 patients. According to the criteria of the Japanese UTI Committee, 5 patients were evaluable, and the overall clinical response was excellent in 2 cases and poor in 3. In bacteriological efficacy, 10 strains of 10 species of organisms were isolated from 5 patients, and 7 strains of them were eradicated. As for subjective or objective side effects, mild dizziness was observed in 1 case, but it disappeared immediately and the treatment was continued. No abnormal changes in laboratory findings were observed.