CLINICAL STUDY ON MT-141 IN THE FIELD OF SURGERY

• Published in: CHEMOTHERAPY Vol. 32; no. Supplement5; pp. 338 - 344
• Main Authors: ICHIKAWA, HIDEYUKI, KARIBE, NORIO, ASATO, SUSUMU, MIZUNO, TADASHI, KOIKE, HIDEO, HAYASH, SHIRO, KIYOSAWA, YUJI, MATSUSHITA, MASAMITSU, SHIOBARA, JUNSHIRO
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1984
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.32.Supplement5_338

MT-141, a novel antibiotic of the cephamycin group, was employed in the treatment of various infectious diseases encountered in the field of surgery, and the drug's clinical efficacy was investigated. MT-141 was administered to a total of 11 patients. In 3 cases, however, the drug was used concomitantly with other antibiotics, or it was administered with the purpose of preventing postoperative infections. Therefore, in these 3 cases, only the safety of the drug was evaluated and no efficacy evaluation was attempted. Administration of this agent was achieved by means of one-shot i. v. injection or i. v. drip infusion, in a dose of 1.0-2.0g, 1-2 times a day. The patients who were the subjects of evaluation of the efficacy of MT-141 consisted of 6 cases of cholangitis and 2 cases of peritonitis, or 8 cases in total. The results of the evaluation of the clinical efficacy of MT-141 were 4 cases of “excellent”, 3 cases of “good” and one case of “poor”. The efficacy rate was thus 88%. No subjective or objective symptoms of side effects were observed. Mild transient fluctuations in the serum GOT and GPT were observed in the laboratory tests in 4 of the cholangitis cases and the one case of peritonitis. These fluctuations were, however, considered not to be related to the effects of MT-141; they might be a pathological symptom of the bile duct infection, or might be due to the effects of a basal disease, surgical treatment, etc. In addition to the efficacy of MT-141 as mentioned above, the drug shows potent in vivo antibacterial effects against gram-negative bacteria. Therefore, MT-141 is thought to be a useful drug in the treatment of infections encountered in the field of surgery.