CLINICAL RESULTS OF CS-807 ON ACUTE EXACERBATION OF CHRONIC BRONCHITIS

• Published in: CHEMOTHERAPY Vol. 36; no. Supplement1; pp. 386 - 390
• Main Authors: HAYASHI, IZUMI, OHNUMA, KIKUO
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1988
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.36.Supplement1_386

Clinical evaluation of CS-807 was performed in nine patients with acute exacerbation of chronic bronchitis. They consisted of six males and three females aged from 46 to 74 years old. CS-807 was given orally to four patients in daily doses of 200mg and five patients in daily doses of 400mg in two divided portions. The duration of administration were four days in one patient, seven days in five and 10 days, 11 days and 14 days in one each. A total of five strains comprising H. influenzae two strains, S. pneumoniae two strains and S. aureus one strain were isolated from the sputum and identified before administration. All strains were eradicated. The clinical efficacy rate was 88.9%(8/9): Excellent in three cases, good in five cases and poor in one case. There were no side effects and abnormal findings in laboratory test values in any of the patients. From the above results, it is concluded that CS-807 is effective, safe and useful new oral cephem.