PHARMACOKINETIC AND CLINICAL STUDIES OF CEFEPIME IN THE FIELD OF OBSTETRICS AND GYNECOLOGY

Cefepime (CFPM), a new cephalosporin, was evaluated for its tissue penetration into female genital organs and clinical usefulness in various obstetric and gynecological infections with the following results. After a single intravenous administration of 1.0g, peak serum concentrations in the cubital...

Full description

Saved in:
Bibliographic Details
Published inCHEMOTHERAPY Vol. 39; no. Supplement2; pp. 350 - 353
Main Authors Matsuda, Seiji, Suzuki, Masaaki, Oh, Kinki
Format Journal Article
LanguageJapanese
Published Japanese Society of Chemotherapy 1991
Subjects
Cefepime
Online AccessGet full text

Cover

More Information
Summary:Cefepime (CFPM), a new cephalosporin, was evaluated for its tissue penetration into female genital organs and clinical usefulness in various obstetric and gynecological infections with the following results. After a single intravenous administration of 1.0g, peak serum concentrations in the cubital vein and uterine artery were 20.8 μg/ml, while genital tissue concentrations were 2.02-20.2 μg/g. CFPM was administered to 11 patients with intrauterine infection, uterine adnexitis, pelvic abscess and pelvic peritonitis. The clinical response in 11 patients was excellent in 1 case, good in 9 cases and unknown in 1 case. Loose stools was observed in 1 case as a side effect.
ISSN:0009-3165
1884-5894
DOI:10.11250/chemotherapy1953.39.Supplement2_350