PHARMACOKINETIC AND CLINICAL STUDIES OF CEFEPIME IN THE FIELD OF OBSTETRICS AND GYNECOLOGY
Cefepime (CFPM), a new cephalosporin, was evaluated for its tissue penetration into female genital organs and clinical usefulness in various obstetric and gynecological infections with the following results. After a single intravenous administration of 1.0g, peak serum concentrations in the cubital...
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Published in | CHEMOTHERAPY Vol. 39; no. Supplement2; pp. 350 - 353 |
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Main Authors | , , |
Format | Journal Article |
Language | Japanese |
Published |
Japanese Society of Chemotherapy
1991
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Subjects | |
Online Access | Get full text |
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Summary: | Cefepime (CFPM), a new cephalosporin, was evaluated for its tissue penetration into female genital organs and clinical usefulness in various obstetric and gynecological infections with the following results. After a single intravenous administration of 1.0g, peak serum concentrations in the cubital vein and uterine artery were 20.8 μg/ml, while genital tissue concentrations were 2.02-20.2 μg/g. CFPM was administered to 11 patients with intrauterine infection, uterine adnexitis, pelvic abscess and pelvic peritonitis. The clinical response in 11 patients was excellent in 1 case, good in 9 cases and unknown in 1 case. Loose stools was observed in 1 case as a side effect. |
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ISSN: | 0009-3165 1884-5894 |
DOI: | 10.11250/chemotherapy1953.39.Supplement2_350 |