CLINICAL APPLICATION OF CS-807, AN ORAL CEPHALOSPORIN ANTIBIOTIC, TO SKIN AND SOFT-TISSUE INFECTIONS

• Published in: CHEMOTHERAPY Vol. 36; no. Supplement1; pp. 620 - 647
• Main Authors: KAWAMURA, HIROSHI, WATANABE, TETSUYA, UENO, KAZUE, WATANABE, KUNITOMO, KAWAGUCHI, HIROSHI, AKIEDA, YOZO, ITOKAWA, KANJI, SUZUKI, TOSHIAKI, KANAZAWA, TERUKO, NAKAYAMA, ISSEI, YAMAJI, EMIKO
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1988; 公益社団法人 日本化学療法学会
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.36.Supplement1_620

Clinical study was made of a new oral cephalosporin antibiotic CS-807 on skin and soft tissue infections. Subject diseases were 144 cases of suppurative atheroma, felon, furuncle, carbuncle, subcutaneous abscess, phlegmon, periproctal abscess, lymphadenitis, lymphangitis, wound infection, paronychia, subareolar abscess, suppurative mastitis, suppurative hydradenitis, omphalitis, suppurative folliculitis, etc. Clinical effects judged by the physicians in charge were: excellent-25 cases; good-96 cases; fair-17 cases; and poor-6 cases out of 144 cases, efficacy rate being 84.0%. On the other hand, clinical effects according to the unified judgement standards were: excellent-83 cases; good-46 cases; fair-7 cases; and poor-8 cases, efficacy rate being 89.6%. Clinical effects by dose were found as: efficacy rate 80.6% in 200mg daily dose group and 85.9% in 400mg group, and stochastically 400 mg group showed superior clinical effect, compared with 200mg group. In bacteriological study, rate of elimination was seen as 86.9% in 61 cases of single infection and 93% in 57 cases of mixed infection. Clinical effect of this drug on the cases in whom preliminarily-administered drug was ineffective showed results more than good in 12 cases out of 15, efficacy rate being 80%. Regarding adverse effect, there was no case who showed subjective or objective symptom among 144 cases. Investigation of abnormal clinical test value was possible in 1 case but no particular abnormality was observed. As a result of investigating MIC in 179 strains of 36 species, 144 strains (80.4%) out of 179 showed a distribution at a level lower than 3.13μg/ml of this drug.