Biliary excretion of loracarbef and its clinical efficacy on surgical infections
The kinetic profile and clinical efficacy of loracarbef (LCBF), a new oral cephem, were investigated.LCBF was administered orally to 9 patients with cholelithiasis at doses of 200mg or 400mg.At 3-5 hours after administration before cholecystectomy, the gallbladder tissue concentration of LCBF was 0....
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Published in | CHEMOTHERAPY Vol. 41; no. Supplement3; pp. 419 - 430 |
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Main Author | |
Format | Journal Article |
Language | English Japanese |
Published |
Japanese Society of Chemotherapy
1993
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Online Access | Get full text |
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Summary: | The kinetic profile and clinical efficacy of loracarbef (LCBF), a new oral cephem, were investigated.LCBF was administered orally to 9 patients with cholelithiasis at doses of 200mg or 400mg.At 3-5 hours after administration before cholecystectomy, the gallbladder tissue concentration of LCBF was 0.20-0.30μg/g at a single dose of 200mg or 400mg, and 0.05-1.25μg/g at doses of 200mg 3 times daily for 3 days.The concentrations in gallbladder bile at 3-5 hours after administration were 0.90-3.90μg/ml and 0.20-5.20μg/ml, respectively. LCBF was administered orally to 4 patients with an indwelling T-tube at a single dose of 200mg.The maximum bile concentration and recovery rate in bile were 3.29-6.55μg/ml and 0.13-0.17%.In 56 patients administered LCBF at doses of 200mg, 2 or 3 times daily for 2 to 15 days, the clinical efficacy was excellent in 3 cases, good in 43, fair in 9, and poor in 1, with the efficacy rate being 82%.No side effects were observed, except for one patient in whom GPT was elevated. |
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ISSN: | 0009-3165 1884-5894 |
DOI: | 10.11250/chemotherapy1953.41.Supplement3_419 |