Acute toxicity studies of Biapenem in mice, rats and dogs

• Published in: CHEMOTHERAPY Vol. 42; no. Supplement4; pp. 121 - 129
• Main Authors: Harada, Yasushi, Yamazaki, Yoshiyuki, Masuda, Tatsuki, Onishi, Mizuo, Sameshima, Hidenobu
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1994
• Subjects: Biapenem
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.42.Supplement4_121

Acute toxicity studies of Biapenem (BIPM), a newly developed carbapenem antibiotic, were conducted intravenously in mice, rats, dogs and infant dogs and subcutaneously in juvenile rats. 1) The minimal lethal doses for mice and rats were over 2000 mg/kg and those for dogs and juvenile rats were over 1000mg/kg. 2) The minimal lethal dose for infant dogs was 500mg/kg. 3) Decreased respiration and prone position were seen immediately after dosing of 2000mg/kg in mice. There were soft feces and a slight decrease in body weight or body weight gain in rats and juvenile rats. 4) There were bloody mucous stool, gelatinous stool, a decrease in spontaneous movement, paleness, hypothermia, tremor and salivation in dogs. A transient decrease in body weight gain was also observed, but no abnormalities were seen in the hematology and serum clinical chemistry. 5) There were a decrease in spontaneous movements, emesis, bloody diarrhea and decreased food consumption on the day of dosing in infant dogs, which recovered by the next day. 6) On the pathological examination, enlarged cecum in rats and slight congestion and hemorrhage in gastro-intestinal mucosa in dogs and infant dogs were observed. There were no abnormal findings in mice and juvenile rats.