CLINICAL STUDY ON TE-031 (A-56268) AGAINST INFECTIONS OF THE URINARY TRACT AND GENITALIA

• Published in: CHEMOTHERAPY Vol. 36; no. Supplement3; pp. 803 - 814
• Main Authors: YAMAGOE, MASANARI, OSADA, TAKAO, NAKANOME, MARIKO, INOUE, TAKEO, HIRANO, AKIHIKO
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1988
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.36.Supplement3_803

We studied the clinical effect of TE-031 (A-56268) in 44 male patients with urethritis and 6 female partners positive for Chlamydia trachomatis (C. T.). The results are as follows. 1. In 17 cases of C. T.-positive, non-gonococcal urethritis (NGU), clinical efficacy was excellent in 14, fair in 2, and poor in 1, with an efficacy rate of 82.4%. 2. In 7 cases of C. T.-positive gonococcal urethritis (GU), clinical efficacy was excellent in 4, good in 1, fair in 1, and poor in 1, with an efficacy rate of 71.4%. 3. In 11 cases of C. T.-negative NGU, clincal efficacy was excellent in 9 and good in 2, with an efficacy rate of 100%. 4. In 9 cases of C. T.-negative GU, clinical efficacy was excellent in 2 cases, fair in 3, and poor in 4, with an efficacy rate of 22.2%. 5. All 6 female partners who had been C. T.-positive but asymptomatic became C. T.-negative after the administration of TE-031, i. e., clinical efficacy was excellent in all cases, with an efficacy rate of 100%. 6. In 30 C. T.- positive cases of all groups, 29 became C. T.-negative at the end of TE-031 administration, the disappearance rate being 96.7%. The disappearance rate of Neisseria gonorrhoeae was low, 67% on day 3 of administration. 7. In all 50 cases examined, neither subjective nor objective side-effects possibly caused by TE-031 were noticed. Laboratory tests in 32 patients before and after TE-031 administration revealed slightly elevated total bilirubin and S-Cr in 2 cases each, and slightly elevated γ-GTP, Al-P, and Na in 1 case each, but these abnormalities were not considered TE-031-induced reactions. Our conclusion, based on the above findings, is that TE-031 is safe, useful and remarkably effective in C. T.-positive and-negative patients with NGU and in C. T.-positive female partners.