EFFECT OF ANTACID ON GASTROINTESTINAL ABSORPTION OF FLEROXACIN IN HEALTHY HUMANS

• Published in: CHEMOTHERAPY Vol. 38; no. Supplement2; pp. 344 - 349
• Main Authors: SAITO, ATSUSHI, SHIMADA, JINGORO, HORI, SEIJI, YOSHIDA, MASAKI, SHIBA, KOHYA, KAJI, MASANOBU, SAITO, SHIZUKI, SAKAI, OSAMU, ISHIDA, RYOZO, KUSAJIMA, HISAO, UCHIDA, HIROSHI
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1990; 公益社団法人 日本化学療法学会
• Subjects: Fleroxacin; 制酸剤; 吸収; 水酸化アルミニウム
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.38.Supplement2_344

We investigated the effect of aluminum hydroxide, an antacid, on the gastrointestinal absorption of fleroxacin in six healthy male volunteers. Two hundred milligrams of fleroxacin was given orally to fasting subjects with and without 1g of dried aluminum hydroxide gel. The peak serum concentrations of unchanged drug were slightly reduced from 2.37 to 1.81μg/ml by concurrent administration of aluminum hydroxide, but no significant changes were found in the area under the serum concentration-time curve, time at which peak serum concentrations were achieved, and elimination half-life in serum. Furthermore, urinary excretion of fleroxacin and total drug over 48 h slightly decreased from 67.2 and 77.6 to 60.3 and 68.3%, respectively. We therefore concluded that the effect of aluminum hydroxide on the gastrointestinal absorption of fleroxacin was less than on other quinolonecarboxylic acid antimicrobial agents.