Relation Between CIA and Principal Variables of Breathing Pattern

• Published in: Nihon Kyōbu Shikkan Gakkai zasshi Vol. 24; no. 11; pp. 1266 - 1274
• Main Author: Tamaya, Seiji
• Format: Journal Article
• Language: Japanese
• Published: Japan The Japanese Respiratory Society 01.11.1986
• Subjects: Adult; Carbon Dioxide; Female; Humans; inspiratory duty cycle; Male; Microcomputers; Middle Aged; P0.1; Pattern Recognition, Automated; Respiration; Respiratory Center - physiology; Software; Time; ventilatory response
• ISSN: 0301-1542; 1883-471X
• DOI: 10.11389/jjrs1963.24.1266

Relationships between output from the central respiratory center and principal variables of breathing patterns were analyzed by a program, designated as MAP (multi-analysis program) using a microcomputer. Written in BASIC with 370 program steps, MAP processes raw data into eleven linear and nonlinear regression lines and displays the graphs on a CRT screen within 70 to 100 seconds. Twenty healthy normal men and women participated as subjects in this study. Ventilatory and occlusion pressure (p0.1) response to CO2 were 1.92±1.13L/mmHg, and 0.57±43cmH2O/mmHg respectively. These data were in accordance with the normal values reported elsewhere. Three basic types of patterns pertaining to the changes of VT, T1 and TE in response to progressive hypercapnia were demonstrated on the newly devised VT, T1 and TE diagrams. Four subject showed no significant changes in T1 and TE (A type). Six subjects demonstrated remarkable shortening of TE (B type). Both T1 and TE were shortened in ten subjects (C type). P0.1 (CIA) related well with mean inspiratory flow VT/T1 in all types. A significant linear correlation between P0.1 and 1/T1 (r=0.968±0.023) were noted in ten subjects in type C. These breathing patterns were not related to anthropometric data nor pulmonary mechanics of the subjects in this study. Inspiratory duty cycle T1/TTOT changed significantly only in type B. While ventilation was increasing, tidal volume increased up to 50% of FEV1.0, and thereafter shortening of T1 resulted in an increase in mean inspiratory flow VT/T1. Effective compliance was 184.0±78.9ml/cmH2O when tidal volume increased from resting level to 50% of FEV1.0. Effective impedance was 7.24±3.02cmH2O/L/sec. The results of this new analysis of breathing patterns were considered to be valuable in studying breathing control.