Treatment of infantile spasms with long-term low dose ACTH

• Published in: No to hattatsu Vol. 24; no. 5; p. 469
• Main Authors: Kuriyama, M, Konishi, Y, Fujii, Y, Yasujima, M, Sudo, M, Konishi, K, Nakamura, K, Ichise, T
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.09.1992
• Subjects: Adrenocorticotropic Hormone - administration & dosage; Adrenocorticotropic Hormone - adverse effects; Drug Administration Schedule; Female; Humans; Hypertension - chemically induced; Hypokalemia - chemically induced; Infant; Male; Spasms, Infantile - drug therapy
• ISSN: 0029-0831
• DOI: 10.11251/ojjscn1969.24.469

We investigated the effect of long-term, low-dose ACTH in 13 patients (10 boys and 3 girls) with infantile spasms who were treated with low-dose ACTH (mean: 0.0081 mg/kg/day). Two patients (one boy and one girl) received this therapy twice because of relapse of tonic spasms. ACTH was injected intramuscularly every morning for 30 days, after which dosage was tapered. The mean observation period was 53.9 months. Complete cessation of seizures was attained in 13 of 15 treatment trials. In one trial, complete cessation was not attained but the number of attacks decreased to less than one-third of that before treatment. In only one trial was treatment not effective. EEG showed good response to this treatment. The side-effects of this therapy were hypertension in 6 patients, hypokalemia in 7, and emotional outburst in 7. Emotional outburst appeared during the early phase of therapy, while the other two side-effects appeared in the later phase and disappeared when ACTH-tapering was begun. Brain shrinkage observed on CT scan was mild in all trials. Five patients have had no relapse. The total dose of ACTH was significantly larger in the group with good outcome than in the group with poor outcome.