Effect of Indomethacin on Leukotriene-induced Contractile Responses in Guinea Pig Trachea and Lung Parenchyma Strips

• Published in: Nihon Kyōbu Shikkan Gakkai zasshi Vol. 22; no. 10; pp. 885 - 889
• Main Authors: Uchida, Yuko, Ishihara, Yoko, Kitamura, Satoshi, Takaku, Fumimaro
• Format: Journal Article
• Language: English; Japanese
• Published: Japan The Japanese Respiratory Society 01.10.1984
• Subjects: Animals; Dose-Response Relationship, Drug; Drug Interactions; Guinea pig; Guinea Pigs; In Vitro Techniques; Indomethacin; Indomethacin - pharmacology; Leukotriene; Lung - drug effects; Lung parenchymal strips; Muscle Contraction - drug effects; Muscle, Smooth - drug effects; SRS-A - pharmacology; Trachea - drug effects; Trachea strips

It has been suggested that leukotrienes (LTs) play very important roles in the pathophysiology of anaphylactic shock and bronchial asthma. In the present investigation we studied the effect of indomethacin on leukotriene-induced contractile responses in guinea pig trachea and lung parenchyma strips...