Cell Mediated Immune Response in Leprosy Lesions
Five biopsies from 2 leprosy patients, tuberculoid (TT), and polar lepromatous (LLp), were studies using immunoperoxidase procedures with monoclonal antibodies. Immunohi-stochemical patterns of them were remarkably differrent. In a TT patient, epithelioid cells and helper/inducer T (Leu 3a+) cells m...
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Published in | Japanese journal of leprosy Vol. 58; no. 2; pp. 85 - 91 |
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Main Authors | , , , |
Format | Journal Article |
Language | Japanese |
Published |
Japan
Japanese Leprosy Association
01.04.1989
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Subjects | |
Online Access | Get full text |
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Summary: | Five biopsies from 2 leprosy patients, tuberculoid (TT), and polar lepromatous (LLp), were studies using immunoperoxidase procedures with monoclonal antibodies. Immunohi-stochemical patterns of them were remarkably differrent. In a TT patient, epithelioid cells and helper/inducer T (Leu 3a+) cells made the central core of a granuloma surrounded by suppressor/cytotoxic T (T8+) cells and B cells, indicating a possible immune-mediated cell response. The distribution of B cells suggests that not only T but also B cells may take part in the formation of the granuloma. In contrast, helper/inducer cells, suppressor/cyto-toxic cells, and macrophages of a LLp patient were admixed uniformly at the site of the lesion, indicating a poor immune response. Although the ENL skin lesion of this LLp patient did not eliminate the bacilli, HLA-DR expression by keratinocytes and increased numbers of helper/inducer cells found in an ENL lesion, comparable to the findings of TT leprosy, suggests that a cell mediated immune response may play some role in the pathogenesis of ENL reaction. |
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ISSN: | 0386-3980 2185-1360 |
DOI: | 10.5025/hansen1977.58.85 |