Significance of Factors of Coagulation and Fibrinolysis in Progression of Lung Cancer

To clarify the significance of factors of coagulation and fibrinolysis in tumor progression, we measured levels of D-Dimer, Thrombin-Anti-Thrombin III complex (TAT), and Plasmin-α2-Anti-Plasmin complex (PAP) in 55 patients with primary lung cancer, and studied the relationship between these paramete...

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Published inNihon Kyōbu Shikkan Gakkai zasshi Vol. 31; no. 2; pp. 180 - 185
Main Authors Nagayama, Masaharu, Tachibana, Akio, Hayakawa, Hiroshi, Sato, Atsuhiko
Format Journal Article
LanguageEnglish
Japanese
Published Japan The Japanese Respiratory Society 01.02.1993
Subjects
Adenocarcinoma - blood
Adenocarcinoma - pathology
alpha-2-Antiplasmin
Antifibrinolytic Agents - analysis
Antithrombin III - analysis
Blood Coagulation Factors - analysis
Carcinoma, Small Cell - blood
Carcinoma, Small Cell - pathology
Carcinoma, Squamous Cell - blood
Carcinoma, Squamous Cell - pathology
Coagulation and fibrinolysis
D-Dimer
Female
Fibrin Fibrinogen Degradation Products - analysis
Fibrinolysin - analysis
Fibrinolysis
Humans
Lung Cancer
Lung Neoplasms - blood
Lung Neoplasms - pathology
Male
Middle Aged
Neoplasm Metastasis
Neoplasm Staging
PAP
Peptide Hydrolases - analysis
Remission Induction
TAT
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Summary:To clarify the significance of factors of coagulation and fibrinolysis in tumor progression, we measured levels of D-Dimer, Thrombin-Anti-Thrombin III complex (TAT), and Plasmin-α2-Anti-Plasmin complex (PAP) in 55 patients with primary lung cancer, and studied the relationship between these parameters and clinical TNM stage. D-Dimer, TAT and PAP increased in parallel with progression of primary tumor and distant metastasis, whereas there was no significant relationship between the progression of nodal involvement and these factors. In 19 patietns, we investigated changes of D-Dimer, PAP and TAT during chemotherapy. These parameters decreased in the partial response group and minor response group, whereas they increased in the progressive disease group. These data suggest that D-Dimer, PAP and TAT determination is useful for evaluation of disorders of coagulation and fibrinolysis related to tumor progression or remission in patients with lung cancer.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0301-1542
1883-471X
DOI:10.11389/jjrs1963.31.180