Effect of Short-Term Hypoxia on Blood Platelet Function Tests of Normal Subjects
We studied how smoking and hypoxia affected blood platelet functions. Eighteen normal subjects (ten non-smokers and eight smokers) inspired 13% oxygen gas and underwent platelet function tests (blood platelet count, MPV, maximum platelet aggregation rate, plasma β-TG, plasma PF-4) were measured just...
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| Published in | Nihon Kyōbu Shikkan Gakkai zasshi Vol. 27; no. 7; pp. 811 - 817 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japan
The Japanese Respiratory Society
01.07.1989
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0301-1542 1883-471X |
| DOI | 10.11389/jjrs1963.27.811 |
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| Abstract | We studied how smoking and hypoxia affected blood platelet functions. Eighteen normal subjects (ten non-smokers and eight smokers) inspired 13% oxygen gas and underwent platelet function tests (blood platelet count, MPV, maximum platelet aggregation rate, plasma β-TG, plasma PF-4) were measured just before inspiration and 30 minutes and 60 minutes after inspiration of that gas. Four principal results were obtained. First, breathing room air, blood platelets count and maximum platelet aggregation rate of smokers were significantly increased compared to those of non-smokers. Second, platelet counts and MPV were not affected by hypoxia in either group. Third, the maximum platelet aggregation rate of smokers was significantly decreased by hypoxia. Fourth, in both groups, the plasma levels of βTG and PF-4 were decreased 30 mimutes after inspiration of the 13% oxgen gas. In non-smokers, 60 minutes after inspiration, these plasma levels recovered to the primary levels. Our study showed that blood platelet functions of normal subjects were affected by hypoxia, and the effects of hypoxia on these functions in these two groups were markedly different. |
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| AbstractList | We studied how smoking and hypoxia affected blood platelet functions. Eighteen normal subjects (ten nonsmokers and eight smokers) inspired 13% oxygen gas and underwent platelet function tests (blood platelet count, MPV, maximum platelet aggregation rate, plasma beta-TG, plasma PF-4) measured just before inspiration and 30 minutes and 60 minutes after inspiration of the gas. Four principal results were obtained. First, breathing room air, blood platelet count and maximum platelet aggregation rate of smokers were significantly increased compared to those of non-smokers. Second, platelet counts and MPV were not affected by hypoxia in either group. Third, the maximum platelet aggregation rate of smokers was significantly decreased by hypoxia. Fourth, in both groups, the plasma levels of beta TG and PF-4 were decreased 30 minutes after inspiration of the 13% oxygen gas. In non-smokers, 60 minutes after inspiration, these plasma levels recovered to the primary levels. Our study showed that blood platelet functions of normal subjects were affected by hypoxia, and the effects of hypoxia on these functions in these two groups were markedly different.We studied how smoking and hypoxia affected blood platelet functions. Eighteen normal subjects (ten nonsmokers and eight smokers) inspired 13% oxygen gas and underwent platelet function tests (blood platelet count, MPV, maximum platelet aggregation rate, plasma beta-TG, plasma PF-4) measured just before inspiration and 30 minutes and 60 minutes after inspiration of the gas. Four principal results were obtained. First, breathing room air, blood platelet count and maximum platelet aggregation rate of smokers were significantly increased compared to those of non-smokers. Second, platelet counts and MPV were not affected by hypoxia in either group. Third, the maximum platelet aggregation rate of smokers was significantly decreased by hypoxia. Fourth, in both groups, the plasma levels of beta TG and PF-4 were decreased 30 minutes after inspiration of the 13% oxygen gas. In non-smokers, 60 minutes after inspiration, these plasma levels recovered to the primary levels. Our study showed that blood platelet functions of normal subjects were affected by hypoxia, and the effects of hypoxia on these functions in these two groups were markedly different. We studied how smoking and hypoxia affected blood platelet functions. Eighteen normal subjects (ten nonsmokers and eight smokers) inspired 13% oxygen gas and underwent platelet function tests (blood platelet count, MPV, maximum platelet aggregation rate, plasma beta-TG, plasma PF-4) measured just before inspiration and 30 minutes and 60 minutes after inspiration of the gas. Four principal results were obtained. First, breathing room air, blood platelet count and maximum platelet aggregation rate of smokers were significantly increased compared to those of non-smokers. Second, platelet counts and MPV were not affected by hypoxia in either group. Third, the maximum platelet aggregation rate of smokers was significantly decreased by hypoxia. Fourth, in both groups, the plasma levels of beta TG and PF-4 were decreased 30 minutes after inspiration of the 13% oxygen gas. In non-smokers, 60 minutes after inspiration, these plasma levels recovered to the primary levels. Our study showed that blood platelet functions of normal subjects were affected by hypoxia, and the effects of hypoxia on these functions in these two groups were markedly different. We studied how smoking and hypoxia affected blood platelet functions. Eighteen normal subjects (ten non-smokers and eight smokers) inspired 13% oxygen gas and underwent platelet function tests (blood platelet count, MPV, maximum platelet aggregation rate, plasma β-TG, plasma PF-4) were measured just before inspiration and 30 minutes and 60 minutes after inspiration of that gas. Four principal results were obtained. First, breathing room air, blood platelets count and maximum platelet aggregation rate of smokers were significantly increased compared to those of non-smokers. Second, platelet counts and MPV were not affected by hypoxia in either group. Third, the maximum platelet aggregation rate of smokers was significantly decreased by hypoxia. Fourth, in both groups, the plasma levels of βTG and PF-4 were decreased 30 mimutes after inspiration of the 13% oxgen gas. In non-smokers, 60 minutes after inspiration, these plasma levels recovered to the primary levels. Our study showed that blood platelet functions of normal subjects were affected by hypoxia, and the effects of hypoxia on these functions in these two groups were markedly different. |
| Author | Narita, Nobuhiro Ako, Hirohumi Kita, Etsuko Mizumoto, Yasuko Kasuga, Hirotomo Nishikawa, Kiyoshi |
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| References | 15) Kennedy, P. S., Ware, J. A., Harak, J. K. & Solis, R. T.: The effect of acute changes in arterial blood pH and PO2 on platelet aggregation. Microvascular Research, 22: 324, 1981. 13) Toivanen, J., Ylikorkala, O. & Viinikka, L.: Effects of smoking and nicotine on human prostacyclin and thromboxane production in vivo and in vitro. Toxicology Applied Pharmacology, 82: 301, 1986. 11) Burghuber, O. C., Punzengruber, Ch., Sinzinger, H., Haber, P. & Silberbauer, K.: Platelet sensitivity to prostacyclin in smokers and non-smokers. Chest, 90: 34, 1986. 3) Tremoli, E., Bertoli, L., Merlini, R., Colli, S., Moderna, P., Mantero, O. & Sirtori, C. R.: Dipyridamole treatment in chronic obstructive airway disease: Effect on platelet regeneration time. Eur. J. Clin. Pharmacol., 23: 423, 1982. 4) Mantero, O., Colli, S., Manderna, P., Cicero, S. L., Bertoli, L. & Tremoli, E.: Pharmacological control of platelet—Vessel wall interaction in patients with chronic obstructive airway disease. G. Ital. Cardiol., 1: 69, 1984. 16) 菊池佑二, 小松さつき, 大島宣雄: 低酸素環境下における血小板凝集抑制作用. Cardioangiology, 19: 381, 1986. 10) Marasin, B., Biondi, M. L., Barbesti, S., Zatta, G. & Agostini, A.: Cigarette smoking and plateled function. Thrombosis Research, 44: 85, 1986. 21) Thompson, C. B., Jakubowski, J. A., Quinn, P. G., Deykin, D. & Valeri, C. R.: Platelet size as a determination of platelet function. J. Lab. Clin. Med., 101: 205, 1983. 6) Johnston, R. V., Belch, J. J. F., McArdle, B. & Jorbes, C. D.: The effect of a nicotine containing chewing gum on the coagulation system in normal volunteers. Thrombosis Research, 35: 99, 1984. 14) 石原陽子, 北村諭, 千治松洋一, 本間日臣: 喫煙と肺の代謝―健常者の血中6-Keto PGF1α, thromboxane B2, 過酸化脂質におよぼす喫煙の影響. 日胸疾会誌, 22: 1122, 1984. 18) Schneider, R. C., Zapol, W. M. & Carvalho, A. C.: Plateelet conseumption and sequestration in severe acute respiratory failure. Am. Rev. Resp. Dis., 122: 445, 1980. 22) Lankey, S. A. & Wohl, H.: Stimulation of human leukocyte elastase by platelet factor 4. J. Clin. Invest., 67: 817, 1981. 1) Nenci, G. G., Berrettini, M., Todisco, T., Costantini, V. & Grasselli, S.: Exausted platelets in chronic obstructive pulmonary disease. Respiration, 44: 71, 1983. 5) Belch, J. J. F., McArdle, B. M., Burns, P., Lowe, G. D. O. & Jorfes, C. D.: The effects of acute smoking on platelet behaviour, fibrinolysis and haemorheology in habitual smokers. Thromb. Haemostas, 51: 6, 1984. 12) Nowak, J., Murray, J. J., Oates, J. A. & Jitz-Gerald, G. A.: Biochemical evidence of a chronic abnormality in platelet and vascular function in healthy individuals who smoke cigarettes. Circulatin, 76: 6, 1987. 8) Rival, J., Riddle, J. M. & Stein, P. D.: Effects of chronic smoking on platelet function. Thrombosis Research, 45: 75, 1987. 2) Cordova, C., Musca, A., Violi, F., Alessandri, C., Perrone, A. & Balsano, F.: Platelet hyperfunction in patients with chronic airway obstruction. Eur. J. Respir. Dis., 66: 9, 1985. 17) Mcdonald, T. P., Cattrell, M. & Clift, R.: Effects of short-term hypoxia on platelet counts of mice. Blood, 51: 165, 1978. 9) Pittilo, R. M., Clark, e J. M. F., Harris, D., Mackie, I. J., Rowles, P. M., Machim, S. J. & Woolf, N.: Cigarette smoking and platelet adhesion. British Journal Haematology, 58: 627, 1984. 7) Dotevall, A., Kutti, J., Teger-Nilson, A. C., Wadenvik, H. & Wilhelmesen, L.: Platelet reactivity, firbrinogen and smoking. Eur. J. Haematol., 38: 55, 1987. 20) Wedzicha, J. A., Catter, F. E. & Empey, D. W.: Platelet size in patients with chronic airflow obstruction with and without hypoxaemia. Thorax, 43: 61, 1988. 19) 橋本憲一, 赤川志のぶ, 田ノ上雅彦, 室田直樹, 大玉信一, 青木延雄, 田中健彦, 光永慶吉, 田上憲次郎, 山崎博男: 血小板活性化を伴う消費亢進をみた肺結核による急性呼吸不全の2症例. 日胸疾会誌, 25: 1110, 1987. |
| References_xml | – reference: 6) Johnston, R. V., Belch, J. J. F., McArdle, B. & Jorbes, C. D.: The effect of a nicotine containing chewing gum on the coagulation system in normal volunteers. Thrombosis Research, 35: 99, 1984. – reference: 8) Rival, J., Riddle, J. M. & Stein, P. D.: Effects of chronic smoking on platelet function. Thrombosis Research, 45: 75, 1987. – reference: 16) 菊池佑二, 小松さつき, 大島宣雄: 低酸素環境下における血小板凝集抑制作用. Cardioangiology, 19: 381, 1986. – reference: 22) Lankey, S. A. & Wohl, H.: Stimulation of human leukocyte elastase by platelet factor 4. J. Clin. Invest., 67: 817, 1981. – reference: 20) Wedzicha, J. A., Catter, F. E. & Empey, D. W.: Platelet size in patients with chronic airflow obstruction with and without hypoxaemia. Thorax, 43: 61, 1988. – reference: 14) 石原陽子, 北村諭, 千治松洋一, 本間日臣: 喫煙と肺の代謝―健常者の血中6-Keto PGF1α, thromboxane B2, 過酸化脂質におよぼす喫煙の影響. 日胸疾会誌, 22: 1122, 1984. – reference: 3) Tremoli, E., Bertoli, L., Merlini, R., Colli, S., Moderna, P., Mantero, O. & Sirtori, C. R.: Dipyridamole treatment in chronic obstructive airway disease: Effect on platelet regeneration time. Eur. J. Clin. Pharmacol., 23: 423, 1982. – reference: 2) Cordova, C., Musca, A., Violi, F., Alessandri, C., Perrone, A. & Balsano, F.: Platelet hyperfunction in patients with chronic airway obstruction. Eur. J. Respir. Dis., 66: 9, 1985. – reference: 7) Dotevall, A., Kutti, J., Teger-Nilson, A. C., Wadenvik, H. & Wilhelmesen, L.: Platelet reactivity, firbrinogen and smoking. Eur. J. Haematol., 38: 55, 1987. – reference: 21) Thompson, C. B., Jakubowski, J. A., Quinn, P. G., Deykin, D. & Valeri, C. R.: Platelet size as a determination of platelet function. J. Lab. Clin. Med., 101: 205, 1983. – reference: 5) Belch, J. J. F., McArdle, B. M., Burns, P., Lowe, G. D. O. & Jorfes, C. D.: The effects of acute smoking on platelet behaviour, fibrinolysis and haemorheology in habitual smokers. Thromb. Haemostas, 51: 6, 1984. – reference: 10) Marasin, B., Biondi, M. L., Barbesti, S., Zatta, G. & Agostini, A.: Cigarette smoking and plateled function. Thrombosis Research, 44: 85, 1986. – reference: 13) Toivanen, J., Ylikorkala, O. & Viinikka, L.: Effects of smoking and nicotine on human prostacyclin and thromboxane production in vivo and in vitro. Toxicology Applied Pharmacology, 82: 301, 1986. – reference: 19) 橋本憲一, 赤川志のぶ, 田ノ上雅彦, 室田直樹, 大玉信一, 青木延雄, 田中健彦, 光永慶吉, 田上憲次郎, 山崎博男: 血小板活性化を伴う消費亢進をみた肺結核による急性呼吸不全の2症例. 日胸疾会誌, 25: 1110, 1987. – reference: 18) Schneider, R. C., Zapol, W. M. & Carvalho, A. C.: Plateelet conseumption and sequestration in severe acute respiratory failure. Am. Rev. Resp. Dis., 122: 445, 1980. – reference: 15) Kennedy, P. S., Ware, J. A., Harak, J. K. & Solis, R. T.: The effect of acute changes in arterial blood pH and PO2 on platelet aggregation. Microvascular Research, 22: 324, 1981. – reference: 9) Pittilo, R. M., Clark, e J. M. F., Harris, D., Mackie, I. J., Rowles, P. M., Machim, S. J. & Woolf, N.: Cigarette smoking and platelet adhesion. British Journal Haematology, 58: 627, 1984. – reference: 17) Mcdonald, T. P., Cattrell, M. & Clift, R.: Effects of short-term hypoxia on platelet counts of mice. Blood, 51: 165, 1978. – reference: 4) Mantero, O., Colli, S., Manderna, P., Cicero, S. L., Bertoli, L. & Tremoli, E.: Pharmacological control of platelet—Vessel wall interaction in patients with chronic obstructive airway disease. G. Ital. Cardiol., 1: 69, 1984. – reference: 1) Nenci, G. G., Berrettini, M., Todisco, T., Costantini, V. & Grasselli, S.: Exausted platelets in chronic obstructive pulmonary disease. Respiration, 44: 71, 1983. – reference: 11) Burghuber, O. C., Punzengruber, Ch., Sinzinger, H., Haber, P. & Silberbauer, K.: Platelet sensitivity to prostacyclin in smokers and non-smokers. Chest, 90: 34, 1986. – reference: 12) Nowak, J., Murray, J. J., Oates, J. A. & Jitz-Gerald, G. A.: Biochemical evidence of a chronic abnormality in platelet and vascular function in healthy individuals who smoke cigarettes. Circulatin, 76: 6, 1987. |
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| Snippet | We studied how smoking and hypoxia affected blood platelet functions. Eighteen normal subjects (ten non-smokers and eight smokers) inspired 13% oxygen gas and... We studied how smoking and hypoxia affected blood platelet functions. Eighteen normal subjects (ten nonsmokers and eight smokers) inspired 13% oxygen gas and... |
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| SubjectTerms | Adult Blood Platelets - physiology Blood platelets count Humans Hypoxemia Hypoxia - physiopathology Male Maximum platelet aggregation rate Platelet Function Tests Smoking Smoking - physiopathology Time Factors β-thromboglobylin |
| Title | Effect of Short-Term Hypoxia on Blood Platelet Function Tests of Normal Subjects |
| URI | https://www.jstage.jst.go.jp/article/jjrs1963/27/7/27_7_811/_article/-char/en https://www.ncbi.nlm.nih.gov/pubmed/2810969 https://www.proquest.com/docview/79301474 |
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