Effect of Short-Term Hypoxia on Blood Platelet Function Tests of Normal Subjects

• Published in: Nihon Kyōbu Shikkan Gakkai zasshi Vol. 27; no. 7; pp. 811 - 817
• Main Authors: Nishikawa, Kiyoshi, Kita, Etsuko, Mizumoto, Yasuko, Kasuga, Hirotomo, Ako, Hirohumi, Narita, Nobuhiro
• Format: Journal Article
• Language: Japanese
• Published: Japan The Japanese Respiratory Society 01.07.1989
• Subjects: Adult; Blood Platelets - physiology; Blood platelets count; Humans; Hypoxemia; Hypoxia - physiopathology; Male; Maximum platelet aggregation rate; Platelet Function Tests; Smoking; Smoking - physiopathology; Time Factors; β-thromboglobylin
• ISSN: 0301-1542; 1883-471X
• DOI: 10.11389/jjrs1963.27.811

We studied how smoking and hypoxia affected blood platelet functions. Eighteen normal subjects (ten non-smokers and eight smokers) inspired 13% oxygen gas and underwent platelet function tests (blood platelet count, MPV, maximum platelet aggregation rate, plasma β-TG, plasma PF-4) were measured just before inspiration and 30 minutes and 60 minutes after inspiration of that gas. Four principal results were obtained. First, breathing room air, blood platelets count and maximum platelet aggregation rate of smokers were significantly increased compared to those of non-smokers. Second, platelet counts and MPV were not affected by hypoxia in either group. Third, the maximum platelet aggregation rate of smokers was significantly decreased by hypoxia. Fourth, in both groups, the plasma levels of βTG and PF-4 were decreased 30 mimutes after inspiration of the 13% oxgen gas. In non-smokers, 60 minutes after inspiration, these plasma levels recovered to the primary levels. Our study showed that blood platelet functions of normal subjects were affected by hypoxia, and the effects of hypoxia on these functions in these two groups were markedly different.