Interleukin-2 Receptor Expression in Pulmonary Granulomatous Diseases

• Published in: Nihon Kyōbu Shikkan Gakkai zasshi Vol. 29; no. 4; pp. 407 - 412
• Main Authors: Ina, Yasutaka, Takada, Katsutoshi, Miyachi, Atsuo, Noda, Masaharu, Sato, Toshihide, Hashiba, Hatsumi, Ito, Shinsuke, Iijima, Naoto, Yamamoto, Masahiko, Morishita, Munehiko, Yoshikawa, Kosho
• Format: Journal Article
• Language: Japanese
• Published: Japan The Japanese Respiratory Society 01.04.1991
• Subjects: Adult; Female; Humans; IFN-γ; IL-2 receptor; Interferon-gamma - physiology; Intracellular signal transduction; Lung Diseases - metabolism; Macrophages - metabolism; Male; Middle Aged; Monocyte Alveolar macrophage; Monocytes - metabolism; Pulmonary Alveoli - cytology; Pulmonary granulomatous diseases; Receptors, Interleukin-2 - metabolism; Sarcoidosis - metabolism; Signal Transduction; Tuberculosis, Pulmonary - metabolism
• ISSN: 0301-1542; 1883-471X
• DOI: 10.11389/jjrs1963.29.407

Interleukin-2 receptor expression (IL-2R) on monocytes and alveolar macrophages (AM) was determined in patients with sarcoidosis and pulmonary tuberculosis. In sarcoidosis and tuberculosis, IL-2R on monocytes was detectable, while it was undetectable in healthy controls. IL-2R on AM in sarcoidosis and tuberculosis was significantly increased as compared to healthy controls. IFN-γ, which has been shown to be increased in sarcoidosis and tuberculosis as compared to healthy controls, induced IL-2R on monocytes in healthy controls, suggesting that IFN-γ is at least in part responsible for the induction or enhancement of IL-2R on monocytes or AM in sarcoidosis and tuberculosis. Phorbol myristate acetate which is known to be protein kinase C (PKC) activator induced IL-2R on monocytes, and PKC inhibitor, H7, inhibited IFN-γ-induced IL-2R on monocytes in healthy controls. Calcium ionophore, A23187, induced IL-2R on monocytes and calmodulin antagonist, W7, inhibited IFN-γ-induced IL-2R on monocytes. Based on these results, it seems that not only the PKC pathway but also the calcium-calmodulin pathway is involved in IFN-γ-induced IL-2R.