Effects of sex hormones on production of prostaglandin E2 by human peripheral monocytes

The effects of sex hormones on the vitro production of prostaglandin (PG) E2 by monocytes were investigated. Monocytes were obtained from heparinized peripheral blood of healthy adults and incubated for 24 hours with lipopolysaccharide (LPS) and sex hormones. After incubation, the medium was assayed...

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Bibliographic Details
Published inJournal of periodontology (1970) Vol. 64; no. 11; p. 1075
Main Authors Miyagi, M, Morishita, M, Iwamoto, Y
Format Journal Article
LanguageEnglish
Published United States 01.11.1993
Subjects
Adult
Analysis of Variance
Estradiol - pharmacology
Female
Gingivitis - etiology
Humans
Male
Monocytes - drug effects
Monocytes - physiology
Progesterone - pharmacology
Prostaglandins E - biosynthesis
Testosterone - pharmacology
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Summary:The effects of sex hormones on the vitro production of prostaglandin (PG) E2 by monocytes were investigated. Monocytes were obtained from heparinized peripheral blood of healthy adults and incubated for 24 hours with lipopolysaccharide (LPS) and sex hormones. After incubation, the medium was assayed for PGE2 by means of radioimmunoassay. PGE2 production by monocytes was enhanced by progesterone. Estradiol reduced PGE2 production at 0.4 ng/ml, but enhanced it at 20 ng/ml. Testosterone reduced PGE2 production. The reduced PGE2 production by monocytes treated with 0.4 ng/ml of estradiol was restored to the control level by addition of progesterone at 20 ng/ml. These results suggest that sex hormones may modulate gingival inflammation mediated by PGE2.
ISSN:0022-3492
DOI:10.1902/jop.1993.64.11.1075