ラットにおける実験的歯周手術後のI型及びIII型collagen形成量の変動に及ぼす没食子酸プロピルの影響
ラット実験的歯周手術後に創傷部に形成されるI型及びIII型collagen量を蛍光免疫染色及び画像解析の手法を用いて半定量的に測定することを試みた。その際, 没食子酸プロピルの歯肉創傷部におけるcollagen形成量に対する影響についても併せて検索した。その結果, プラセボ群におけるI型collagen形成量は創傷後3～7日目の間有意な変化がないのに対し, III型collagen形成量は創傷後5, 7日目で有意な増加を示した。一方, 没食子酸プロピル投与群ではI型collagen形成量は創傷後5日目以降, さらにIII型collagen形成量は創傷後3日目より5日目までプラセボ群に比較して有...
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| Published in | 日本歯周病学会会誌 Vol. 37; no. 1; pp. 84 - 96 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
特定非営利活動法人 日本歯周病学会
1995
日本歯周病学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0385-0110 1880-408X |
| DOI | 10.2329/perio.37.84 |
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| Abstract | ラット実験的歯周手術後に創傷部に形成されるI型及びIII型collagen量を蛍光免疫染色及び画像解析の手法を用いて半定量的に測定することを試みた。その際, 没食子酸プロピルの歯肉創傷部におけるcollagen形成量に対する影響についても併せて検索した。その結果, プラセボ群におけるI型collagen形成量は創傷後3～7日目の間有意な変化がないのに対し, III型collagen形成量は創傷後5, 7日目で有意な増加を示した。一方, 没食子酸プロピル投与群ではI型collagen形成量は創傷後5日目以降, さらにIII型collagen形成量は創傷後3日目より5日目までプラセボ群に比較して有意な増加を示した。以上の結果から, 実験的歯周手術後の創傷部ではまずIII型collagen形成が先行するのに対し, I型collagen形成は少なくとも術後7日までは著明な変化を示さないこと, さらに没食子酸プロピルはこれらのcollagen形成を促進させることが示唆された。 |
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| AbstractList | ラット実験的歯周手術後に創傷部に形成されるI型及びIII型collagen量を蛍光免疫染色及び画像解析の手法を用いて半定量的に測定することを試みた. その際, 没食子酸プロピルの歯肉創傷部におけるcollagen形成量に対する影響についても併せて検索した. その結果, プラセボ群におけるI型collagen形成量は創傷後3～7日目の間有意な変化がないのに対し, III型collagen形成量は創傷後5, 7日目で有意な増加を示した. 一方, 没食子酸プロピル投与群ではI型collagen形成量は創傷後5日目以降, さらにIII型collagen形成量は創傷後3日目より5日目までプラセボ群に比較して有意な増加を示した. 以上の結果から, 実験的歯周手術後の創傷部ではまずIII型collagen形成が先行するのに対し, I型collagen形成は少なくとも術後7日までは著明な変化を示さないこと, さらに没食子酸プロピルはこれらのcollagen形成を促進させることが示唆された. |
| Author | 野村, 隆 高橋, 徳也 小川, 伸之 一戸, 千華子 井上, 紳太郎 久保田, 健彦 原, 耕二 大石, 祐一 |
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| DOI | 10.2329/perio.37.84 |
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T., Matsubara, M., Kublin, C., Tessier, M. J., Cintron, C. and Fini, M. E.: Stromal fibroblasts synthetic collagenase and stromelysin during long-term tissue remodeling. J. Cell. Sci., 104: 1001-1011, 1993. Moore, G. G. I. and Swingle, K. F.: 2, 6-di-tertbutyl-4- (2'-thenoyl) phenol (R-830) : A novel nonsteroidal anti-inflammatory agent with antioxidant properties. Agent and Actions, 12: 674-683, 1982. 大石祐一, 太田英子, 井上紳太郎: 没食子酸プロピルのコラゲナーゼ阻害作用機構と構造活性相関. 生化学 (弟67回日本生化学会大会発表抄録集), 66: 929, 1994. Grevstad, H. J.: Collagen deposition during wound repair in rat gingiva. Scand. J. Dent. Res., 96: 561-568, 1988. Perry, H. D., Hodes, L. W., Seedor, J. A., Donnenfeld, E. D., McNamara, T. F. and Golub, L. M.: Effect of doxycycline hyclate on corneal epithelial wound healing in the rabbit alkali-burn model. Preliminary observations. Cornea, 12: 379-382, 1993. Narayanan, A. S. and Page, R. C.: Connective tissues of the periodontium. A summary of current work. Collagen Rel. Res., 3: 33-64, 1983. 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Science, 185: 529-531, 1974. Burns, F. R., Gray, R. D. and Paterson, C. A.: Inhibition of alkali-induced corneal ulceration and perforation by a thiol peptide. Invest. Ophtalmol. Vis. Sci., 31: 107-114, 1990. Ofuji, Y., Suzuki, T., Yoshie, H., Hara, K. and Adachi, M.: The effects of ovomacroglobulin on gingival wound healing in rats. Periodont. Clin. Invest., 14: 13-22, 1992. McCachren, S. S.: Expression of metalloproteinases and metalloproteinase inhibitor in human arthritic synovium. Arthritis. Rheum., 34: 1085-1093, 1991. Weiss, S. J.: Tissue destruction by neutrophils. New Engl. J. Med., 320: 365-376, 1989. 佐藤聡, 鴨井久一: ラット歯周組織の創傷治癒に関する免疫組織化学的研究-実験的フラップ手術後のI型コラーゲン, III型コラーゲン, フィプロネクチンの局在. 日歯周誌, 33: 541-576, 1991. Nomura, T., Takahashi, T. and Hara, K.: Expression of TIMP-1, TIMP-2 and collagenase mRNA in periodontitis-affected human gingival tissue. J. Periodont. Res., 28: 354-362, 1993. Ando, Y., Inoue, M., Utumi, T., Morino, Y. and Araki, S.: Synthesis of acylated SOD derivatives which bind to the biomembrane lipid surface and dismutate extracellular superoxide radicals. FEBS lett., 240: 216-220, 1988. Tung, P. S., Domenicucci, C., Wasi, S. and Sodek, J.: Specific immunohistochemical localization of osteonectin and collagen types I and III in fetal and adult porcine dental tissues. J. Histochem. Cytochem., 33: 531-540, 1985. Cho, M. I., Garant, P. R. and Lee, Y. L.: Immunohistochemical localization of collagen (I and III) and fibronectin in inflamed and noninflamed gingival connective tissue and sulcular fluid of beagle dogs. J. Perodont. Res., 19: 683-641, 1984. Stricklin, G. P. and Hoidaal, J. R.: Oxidantmediated inactivation of TIMP: Birkedal-Hansen, H., Werb, Z., Welgus, H., Wart, H. V. (eds), Matrix metalloproteinases and inhibitors, Gustav Fischer Verlag, New York, 1992, 325. Betz, P., Nerlich, A., Wilske, J., Tubel, J., Penning, R. and Eisenmenger, W.: Immunohistochemical localization of collagen types I and IV in human skin wounds. Int. J. Legal. Med., 106: 31-34, 1993. Kossakowska, A. E., Urbanski, S. J. and Edwards, D. R.: Tissue inhibitor of metalloproteinases-1 TIMP-1) RNA is expressed (at elevated levels in malignant non-Hodgkin's lymphomas. Blood, 77: 2475-2481, 1991. Saarialho-kere, U. K., Chang, E. S., Welgus, H. G. and Parks, W. C.: Distinct localization of collagenase and tissue inhibitor of metalloproteinases expression in wound healing associated with ulcerative pyogenic granuloma. J. Clin. Invest., 90: 1952-1957, 1992. Sodek, J. and Overall, C. M.: Matrix metalloproteinases in periodontal tissue remodeling: Birkedal-Hansen, H., Werb, Z., Welgus, H., Wart, H. V. (eds), Matrix metalloproteinases and inhibitors, Gustav Fischer Verlag, New York, 1992, 352-362. Reddi, A. H.: Extracellular matrix and development. Piez, K. A., Reddi, A. H. (eds), Extracellular matrix biochemistry. Elsevier Science Publishing Co., New York, 1984, 388. Schultz, G., Chegini, N., Grant, M., Khaw, P. and MacKay, S.: Effects of growth factors on corneal wound healing. Acta. Ophthalmol., 70 (Suppl.) : 60-66, 1992. Stetler-Stevenson, W. G., Brown, P. D., Onisto, M., Levy, A. T. and Liotta, L. A.: Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues. J. Biol. Chem., 265: 13933-13938, 1990. Manson, P. N., Anthenelli, R. M., Im, M. J., Bulkley, G. B. and Hoopes, J. E.: The role of oxygen-free radicals in ischemic tissue injury in island skin flaps. Ann. Surg., 198: 87-90, 1983. Mira, M. L., Azevedo, M. S. and Manso, C.: The neutralization of hydroxy radical by silibin, sorbinil and bendazac. Free Rad. Res. Comms., 4: 125-129, 1987. Saarialho-kere, U. K., Kovacs, S. O., Pentland, A. P., Olerund, J. E., Welgus, H. G. and Parks, W. 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| References_xml | – reference: Ando, Y., Inoue, M., Utumi, T., Morino, Y. and Araki, S.: Synthesis of acylated SOD derivatives which bind to the biomembrane lipid surface and dismutate extracellular superoxide radicals. FEBS lett., 240: 216-220, 1988. – reference: Ingman, T., Sorsa, T., Suomalainen, K., Halinen, S., Lindy, O., Lauhio, A., Saari, H., Konttinen, Y. T. and Golub, L. M.: Tetracycline inhibition and the cellular source of collagenase in gingival crevicular fluid in different periodontal diseases. A review article. J. Periodontol., 64: 82-88, 1993. – reference: Mira, M. L., Azevedo, M. S. and Manso, C.: The neutralization of hydroxy radical by silibin, sorbinil and bendazac. Free Rad. Res. Comms., 4: 125-129, 1987. – reference: Betz, P., Nerlich, A., Wilske, J., Tubel, J., Penning, R. and Eisenmenger, W.: Immunohistochemical localization of collagen types I and IV in human skin wounds. Int. J. Legal. Med., 106: 31-34, 1993. – reference: Nomura, T., Takahashi, T. and Hara, K.: Expression of TIMP-1, TIMP-2 and collagenase mRNA in periodontitis-affected human gingival tissue. J. Periodont. Res., 28: 354-362, 1993. – reference: Moore, G. G. I. and Swingle, K. F.: 2, 6-di-tertbutyl-4- (2'-thenoyl) phenol (R-830) : A novel nonsteroidal anti-inflammatory agent with antioxidant properties. Agent and Actions, 12: 674-683, 1982. – reference: Schultz, G., Chegini, N., Grant, M., Khaw, P. and MacKay, S.: Effects of growth factors on corneal wound healing. Acta. Ophthalmol., 70 (Suppl.) : 60-66, 1992. – reference: 佐藤聡, 鴨井久一: ラット歯周組織の創傷治癒に関する免疫組織化学的研究-実験的フラップ手術後のI型コラーゲン, III型コラーゲン, フィプロネクチンの局在. 日歯周誌, 33: 541-576, 1991. – reference: Villar, A., Gasco, M. A. and Alcaraz, M. J.: Antiinflammatory and and-ulcer properties of hypolaetin-8-glucoside, a novel plant flavonoid. J. Pham. Pharmacol., 36: 820-823, 1984. – reference: Narayanan, A. S. and Page, R. C.: Connective tissues of the periodontium. A summary of current work. Collagen Rel. Res., 3: 33-64, 1983. – reference: Cho, M. I., Lee, Y. L. and Garant, P. R.: Immunocytochemical localization of extracellular matrix components in beagle periodontium: I. collagen types I and III in healthy gingival connective tissue. J. Perodont. Res., 22: 313-319, 1987. – reference: Page, R. C.: The role of inflammatory mediators in the pathogenesis of periodontal disease. J. Periodont. Res., 26: 230-242, 1991. – reference: Stetler-Stevenson, W. G., Brown, P. D., Onisto, M., Levy, A. T. and Liotta, L. A.: Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues. J. Biol. Chem., 265: 13933-13938, 1990. – reference: Chavrier, C., Couble, M. L., Magloire, H. and Grimaud, J. A.: Connective tissue organization of healthy human gingiva. Ultrastructural localization of collagen types I -III-IV. J. Periodont. Res., 19: 221-229. 1984. – reference: Tung, P. S., Domenicucci, C., Wasi, S. and Sodek, J.: Specific immunohistochemical localization of osteonectin and collagen types I and III in fetal and adult porcine dental tissues. J. Histochem. Cytochem., 33: 531-540, 1985. – reference: Bonadio, J. F., Sage, H., Cheng, F., Bernstein, J. and Striker, G. E.: Localization of collagen types IV and V, laminin, and heparan sulfate proteoglycan to the basal lamina of kidney epithelial cells in transfilter metanephric culture. Am. J. Pathol., 116: 289-296, 1984. – reference: Grevstad, H. J.: Collagen deposition during wound repair in rat gingiva. Scand. J. Dent. Res., 96: 561-568, 1988. – reference: Stricklin, G. P. and Hoidaal, J. R.: Oxidantmediated inactivation of TIMP: Birkedal-Hansen, H., Werb, Z., Welgus, H., Wart, H. V. (eds), Matrix metalloproteinases and inhibitors, Gustav Fischer Verlag, New York, 1992, 325. – reference: Girard, M. T., Matsubara, M., Kublin, C., Tessier, M. J., Cintron, C. and Fini, M. 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Invest., 14: 13-22, 1992. – reference: Alison, M. R.: Repair and regenerative responses: McGee, J. O' D., Isaacson, P. G., Wright. N. A. (eds), Oxford Textbook of Pathology, Oxford University Press, Oxford, 1992, 365-389. – reference: Salo, T., Lyons, J. G., Rahemtulla, F., Birkedal-Hansen, H. and Larjava, H.: Transforming growth factor-beta 1 up-regulates type IV collagenase expression in cultured human keratinocytes. J. Biol. Chem., 266: 11436-11441, 1991. – reference: 大石祐一, 太田英子, 井上紳太郎: 没食子酸プロピルのコラゲナーゼ阻害作用機構と構造活性相関. 生化学 (弟67回日本生化学会大会発表抄録集), 66: 929, 1994. – reference: Saarialho-kere, U. K., Kovacs, S. O., Pentland, A. P., Olerund, J. E., Welgus, H. G. and Parks, W. C. : Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing. J. Clin. Invest., 92: 2858-2866, 1993. – reference: Kossakowska, A. E., Urbanski, S. J. and Edwards, D. 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| Snippet | ラット実験的歯周手術後に創傷部に形成されるI型及びIII型collagen量を蛍光免疫染色及び画像解析の手法を用いて半定量的に測定することを試みた。その際, 没食子酸プロピルの歯肉創傷部におけるcollagen形成量に対する影響についても併せて検索した。その結果,... ラット実験的歯周手術後に創傷部に形成されるI型及びIII型collagen量を蛍光免疫染色及び画像解析の手法を用いて半定量的に測定することを試みた. その際, 没食子酸プロピルの歯肉創傷部におけるcollagen形成量に対する影響についても併せて検索した. その結果,... |
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| SubjectTerms | ラット 免疫組織化学 歯肉創傷治癒 没食子酸プロピル 画像解析 |
| Title | ラットにおける実験的歯周手術後のI型及びIII型collagen形成量の変動に及ぼす没食子酸プロピルの影響 |
| URI | https://www.jstage.jst.go.jp/article/perio1968/37/1/37_1_84/_article/-char/ja http://mol.medicalonline.jp/en/journal/download?GoodsID=cp9perlo/1995/003701/008&name=0084-0096j |
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