A CLINICAL STUDY ON 6059-S IN THE FIELD OF SURGERY

• Published in: CHEMOTHERAPY Vol. 28; no. Supplement7; pp. 681 - 693
• Main Authors: SAKAI, KATSUJI, FUJIMOTO, MIKIO, UEDA, TAKAMI, KAWABATA, NORIYUKI, SASAKI, TAKEYA, MAEDA, SADAKUNI, SAWADA, AKIRA, MASADA, AKINORI, KAWASHIMA, MASAYOSHI, KITANO, FUKUO, DOI, SUSUMU
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 01.01.1980
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.28.Supplement7_681

6059-S, a new oxacephem derivative, was investigated on its serum level, urinary ecretion and bile concentration. 1) Following intravenous drip infusion of each 1 g of 6059-S, the average serum level reached its peak of 45.3 μg/ml and gradually fell to 4.9 μg/ml after 8 hours. 2) The cumulative urinaly excretion rate was 51.1% within 4 hours and reached 64.3% after 8 hours. 3) Biliary excretion was investigated on 2 patients following intravenous one shot and drip infusion of each 1 g of 6059-S.Biliary concentrations reached at their peak levels 2 or 3 hours after administrations approximate their serum peak levels measured simultaneously. 4) 6059-5 was given to 41 patients with various infections in the field of surgery.The results of effectiveness obtained were as follows: excellent in 18, good in 12, fair in 4, poor in 6 cases and unknown in 1 case.Efficacy rate was 75.0%. 5) No serious side effect was noted except transient elevation of serum-GOT and GPT in 5 of all 41 cases.