PHARMACOKINETICS OF CINOXACIN IN PATIENTS WITH IMPAIRED RENAL FUNCTION

The pharmacokinetics of cinoxacin, a new synthetic antibacterial agent, were examined in 6 healthy volunteers and 12 patients with different endogeneous creatinine clearances (Ccr) on the basis of a one-compartment open model. Each subject received a single 400mg oral dose of cinoxacin, and serum an...

Full description

Saved in:
Bibliographic Details
Published inCHEMOTHERAPY Vol. 28; no. Supplement4; pp. 133 - 138
Main Authors OHKAWA, MITSUO, SUGATA, TOSHIAKI, KURODA, KYOICHI, OKASHO, AKIRA, SAWAKI, MASARU, KAWAGUCHI, KOHEI, TAKANO, MANABU
Format Journal Article
LanguageJapanese
Published Japanese Society of Chemotherapy 01.01.1980
Online AccessGet full text
ISSN0009-3165
1884-5894
DOI10.11250/chemotherapy1953.28.Supplement4_133

Cover

More Information
Summary:The pharmacokinetics of cinoxacin, a new synthetic antibacterial agent, were examined in 6 healthy volunteers and 12 patients with different endogeneous creatinine clearances (Ccr) on the basis of a one-compartment open model. Each subject received a single 400mg oral dose of cinoxacin, and serum and urinary concentrations of free cinoxacin and cinoxacin conjugate were measured by a fluorometric method. The mean peak concentration of free cinoxacin in serum was achieved 3 hours after administration in normal subjects. The mean serum half-life of free cinoxacin was calculated for 66 minutes in normal subjects, and increased in patients along with increasing impairment of renal function. A significant correlation between the elimination rate constant and Ccr was demonstrated (p<0.001). In normal subjects, 62% of the drug was excreted in the urine as free cinoxacin within the first 12 hours, 95% as total cinoxacin including cinoxacin conjugate. The urinary excretion rate declined gradually in patients as a degree of renal impairment advanced.
ISSN:0009-3165
1884-5894
DOI:10.11250/chemotherapy1953.28.Supplement4_133