抗インフルエンザ薬oseltamivirの電気生理学的および抗心房細動作用の解析：発作性心房細動モデル犬での検討

• Published in: 日本薬理学会年会要旨集 p. 3-Y-G1-2
• Main Authors: 長澤（萩原）, 美帆子, 神林, 隆一, 川合, 眞一, 布井, 啓雄, 後藤, 愛, 中瀬古（泉）, 寛子, 武井, 義則, 廣川, 佳貴, 松本, 明郎, 杉山, 篤
• Format: Journal Article
• Language: Japanese
• Published: 公益社団法人 日本薬理学会 2021
• Subjects: antiviral agent; arrhythmia; drug efficacy; electrocardiography (ECG)
• ISSN: 2435-4953
• DOI: 10.1254/jpssuppl.94.0_3-Y-G1-2

Introduction: Anti-influenza drug oseltamivir has been reported to suppress atrial fibrillation (Af) in vitro; however, since information of oseltamivir is lacking regarding in vivo anti-Af property, we studied it using the paroxysmal Af canine model.Methods: Oseltamivir in doses of 3 and 30 mg/kg/10 min was intravenously infused to the isoflurane-anesthetized, chronic atrioventricular block dogs (n=4) under monitoring electrophysiological variables, in which Af was induced by 10 s of burst pacing on atrial septum.Results: The high dose of oseltamivir decreased sinoatrial/idioventricular rate and mean blood pressure, whereas no significant change was observed by its low dose. Oseltamivir delayed inter-atrial conduction in dose- and frequency-dependent manners, whereas it prolonged atrial effective refractory period in dose-dependent but frequency-independent manners. The high dose prolonged ventricular effective refractory period, which was not detected by the low dose. Oseltamivir decreased Af incidence and shortened Af duration in a dose-dependent manner along with prolongation of Af cycle length.Conclusion: Oseltamivir effectively suppressed the inducibility of paroxysmal Af and shortened its duration in vivo, which may depend on the delay in inter-atrial conduction and prolongation of atrial effective refractory period.