高食塩負荷により惹起される高血圧および行動異常は末梢炎症反応を伴う

• Published in: 日本薬理学会年会要旨集 p. 1-Y-F2-4
• Main Authors: 國澤, 和生, 窪田, 悠力, 山本, 康子, 毛利, 彰宏, 齋藤, 邦明, 手塚, 裕之, 長尾, 静子, 鍋島, 俊隆, 釘田, 雅則, 倉橋, 仁美, 長谷川, 眞也
• Format: Journal Article
• Language: Japanese
• Published: 公益社団法人 日本薬理学会 2021
• Subjects: hypertension; tau protein
• ISSN: 2435-4953
• DOI: 10.1254/jpssuppl.94.0_1-Y-F2-4

High salt (HS) intake is known as a risk factor for hypertension and dementia. However, an involvement of the brain-peripheral interaction in the HS-induced hypertension and cognitive dysfunction is still unclear. In this study, we confirmed the effect of HS intake on the blood pressure and cognitive and emotional functions in mice. Mice showed hypertension and impairments of object recognition memory in novel object recognition test and social behavior in social interaction test 12 weeks after HS intake. We investigated the mechanism of HS intake-induced hypertension and abnormal behaviors. HS intake increased phosphorylation of tau and decreased phosphorylation of Ca2+ / calmodulin-dependent protein kinase II (CaMKII) and expression of PSD95 in the prefrontal cortex and hippocampus, suggesting HS intake induces neuronal dysfunction. On the other hand, HS intake increased mRNA levels of inducible nitric oxide synthase (iNOS) and serum amyloid A (SAA) in the small intestine and picolinic acid levels in the serum, suggesting HS intake induces peripheral inflammatory response. The present findings suggest that HS intake induces hypertension and abnormal behaviors with peripheral inflammatory response.