獲得後のNMDA受容体阻害は空間記憶保持を向上させる

• Published in: 心理学研究 Vol. 84; no. 6; pp. 618 - 624
• Main Authors: 篠原, 恵介, 畑, 敏道
• Format: Journal Article
• Language: Japanese
• Published: 公益社団法人 日本心理学会 25.02.2014
• Subjects: forgetting; Morris water maze; N-methyl-D-aspartate receptor; rat; spatial reference memory
• ISSN: 0021-5236; 1884-1082
• DOI: 10.4992/jjpsy.84.618

We investigated the effect of a post-training chronic infusion of N-methyl- d -aspartate (NMDA) receptor blocker on retention of spatial reference memory in rats. In Experiment 1, we trained 4 groups of rats for 4 days (4 trials/day) in the Morris water maze task. In a single probe trial after retention intervals of 1, 7, 14, and 28 days, the 1-day group showed more goal crossings than shown by the other 3 groups. In Experiment 2, a chronic infusion of the NMDA receptor antagonist d -2-amino-5-phosphonovaleric acid ( d -AP5) or a control vehicle into the lateral ventricle was initiated 1 day after the training session, and continued for 6 days. In the subsequent probe trial (7 days after training), the rats that had received the d -AP5 infusion showed significantly more goal crossings than the controls. These findings suggest that an NMDA receptor blockade following acquisition facilitates retention of spatial reference memory.