自然発症高血圧ラットの膀胱機能障害に対するロサルタンの効果

• Published in: 日本薬理学会年会要旨集 p. 1-B-P-050
• Main Authors: 清水, 孝洋, 齊藤, 源顕, 東, 洋一郎, 倉林, 睦, 清水, 翔吾, 長尾, 佳樹, Suo, Zou
• Format: Journal Article
• Language: Japanese
• Published: 公益社団法人 日本薬理学会 2022
• Subjects: angiotensin receptor; hypertension; spontaneously hypertensive rat (SHR); urine
• ISSN: 2435-4953
• DOI: 10.1254/jpssuppl.96.0_1-B-P-050

Purpose: Our previous report showed aging caused bladder dysfunction in spontaneously hypertensive rats (SHRs). In this study, we investigated the protective effects of an antihypertensive drug, angiotensin II type 1 receptor blocker losartan on bladder dysfunction in aged SHRs.Materials and Methods: Thirty-six-week-old male SHRs were orally treated with losartan (0, 3 or 10 mg/kg) once daily for 18 weeks. Vehicle-treated Wistar Kyoto rats (WKYs) were used as normotensive controls. Results: Vehicle-treated SHRs had significantly higher detrusor thickness, bladder arterial wall thickness compared to vehicle-treated WKYs. Moreover, SHRs showed significantly higher single voided volume (SVV), post-voiding residual urine volume (RV), bladder capacity (BC), and intercontraction interval (ICI) and lower voiding efficiency compared to vehicle-treated WKYs. A low dose of losartan decreased RV, BC and ICI but not mean blood pressure in SHRs. A high dose of losartan ameliorated changes in mean blood pressure, detrusor thickness, bladder arterial wall thickness, SVV, RV, BC and ICI in SHRs.  Conclusion: Treatment with losartan ameliorated bladder dysfunction in aged SHRs.