顎下リンパ節の腫脹を契機に診断に至った血管免疫芽球性T細胞リンパ腫の1例

Angioimmunoblastic T-cell lymphoma (AITL) is one of the subtypes of non-Hodgkin lymphoma. The neoplasm is characterized by aggressive, rapid growth and a poor prognosis. A standard treatment protocol has not been established. In our literature review, only one case of AITL of the head and neck was d...

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Published in日本口腔外科学会雑誌 Vol. 65; no. 4; pp. 257 - 262
Main Authors 鵜澤, 成一, 末松, 基生, 松宮, 由香, 竹下, 彰範, 今井, 智章, 宇佐美, 悠
Format Journal Article
LanguageJapanese
Published 社団法人 日本口腔外科学会 20.04.2019
Subjects
血管免疫芽球性Ｔ細胞リンパ腫
顎下リンパ節
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ISSN0021-5163
2186-1579
DOI10.5794/jjoms.65.257

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Abstract Angioimmunoblastic T-cell lymphoma (AITL) is one of the subtypes of non-Hodgkin lymphoma. The neoplasm is characterized by aggressive, rapid growth and a poor prognosis. A standard treatment protocol has not been established. In our literature review, only one case of AITL of the head and neck was diagnosed. We report a case of AITL diagnosed by submandibular lymph node biopsy. A 74-year-old woman visited our department because of a swelling in submandibular region. Magnetic resonance imaging showed multiple lymphadenopathy in the bilateral submandibular region. Positron-emission tomography-computed tomography showed the abnormal uptake of FDG in lymph nodes of the entire body. A submandibular lymph node biopsy was performed, and AITL was diagnosed histopathologically. CHOP or Hyper-CVAD, which are standard treatments for non-Hodgkin lymphoma, were proposed, but were not accepted by the patient. Alternatively, anti-CCR4 antibody therapy was conducted, but resulted in poor control of the disease. Finally, palliative care was performed until the patient died of the disease.
AbstractList Angioimmunoblastic T-cell lymphoma (AITL) is one of the subtypes of non-Hodgkin lymphoma. The neoplasm is characterized by aggressive, rapid growth and a poor prognosis. A standard treatment protocol has not been established. In our literature review, only one case of AITL of the head and neck was diagnosed. We report a case of AITL diagnosed by submandibular lymph node biopsy. A 74-year-old woman visited our department because of a swelling in submandibular region. Magnetic resonance imaging showed multiple lymphadenopathy in the bilateral submandibular region. Positron-emission tomography-computed tomography showed the abnormal uptake of FDG in lymph nodes of the entire body. A submandibular lymph node biopsy was performed, and AITL was diagnosed histopathologically. CHOP or Hyper-CVAD, which are standard treatments for non-Hodgkin lymphoma, were proposed, but were not accepted by the patient. Alternatively, anti-CCR4 antibody therapy was conducted, but resulted in poor control of the disease. Finally, palliative care was performed until the patient died of the disease.
Author 松宮, 由香
末松, 基生
宇佐美, 悠
今井, 智章
鵜澤, 成一
竹下, 彰範
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References 2) Federico M, Rudiger T, et al : Clinicopathologic characteristics of angioimmunoblastic T-cell lymphoma : analysis of the international peripheral T-cell lymphoma project. J Clin Oncol 23: 240-246, 2013.
13) Yang G, Abdelhalim F, et al : Composite Angioimmunoblastic T-Cell Lymphoma and B-Cell Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Involving Both Lymph Node and Bone Marrow With Digital Gangrene. Hematopathology 3: 14-21, 2018.
14) Wang Y, Xie B, et al : Development of angioimmunoblastic T-cell lymphoma after treatment of diffuse large B-cell lymphoma: a case report and review of literature. Int J Clin Exp Pathol 7: 3432-3438, 2014.
20) Attygalle AD, Kyriakou C, et al : Histologic evolution of angioimmunoblastic T-cell lymphoma in consecutive biopsies: clinical correlation and insights into natural history and disease progression. Am J Surg Pathol 31: 1077-1088, 2007.
15) Suefuji N, Niino D, et al : Clinicopathological analysis of a composite lymphoma containing both T- and B-cell lymphomas. Pathol Int 62: 690-698, 2012.
10) 伊豆津宏二：血管免疫芽球性T細胞リンパ腫．Nippon Rinsho 72: 519-523, 2014.
17) Ishida T, Utsunomiya A, et al : Clinical significance of CCR4 expression in adult T-cell leukemia/lymphoma: its close association with skin involvement and unfavorable outcome. Clin Cancer Res 9: 3625-3634, 2003.
18) Ishida T, Inagaki H, et al : CXC chemokine receptor 3 and CC chemokine receptor 4 expression in T-cell and NK-cell lymphomas with special reference to clinicopathological significance for peripheral T-cell lymphoma, unspecified. Clin Cancer Res 10: 5494-5500, 2004.
11) 田丸淳一， 川野竜太郎， 他：悪性リンパ腫の病理．日耳鼻 112: 465-473, 2009.
3) The world health organization classification of malignant lymphomas in japan : incidence of recently recognized entities. Lymphoma Study Group of Japanese Pathologists. Pathol Int 50: 696-702, 2000.
21) Argyris PP, Koutlas IG, et al : Angioimmunoblastic T-cell lymphoma of the oral cavity presenting as gingival mass : report of the histopathologic and molecular characteristics of an unusual case featuring clonal T-cell receptor γ gene rearrangement by polymerase chain reaction. Oral Surg Oral Med Oral Pathol Oral Radiol 118: e198-204, 2014.
6) 鈴木律朗：T/NK細胞リンパ腫ガイドライン．臨血 54: 1764-1769, 2013.
16) 義江　修：ケモカイン受容体CCR4とHTLV-1感染，ATL発がん. ウイルス 58: 125-140, 2008.
1) 青笹克之， 森井英一：血管免疫芽球性T細胞リンパ腫；リンパ球増殖疾患　癌診療指針のための病理診断プラクティス．中山書店， 東京， 2010, 227-235 頁
7) (一社) 日本血液学会：末梢性T細胞リンパ腫．造血器腫瘍診療ガイドライン : 2013. Available at: http://www.jshem.or.jp/gui-hemali/2_7.html Accessed August 20, 2016.
9) 岡本昌隆：血管免疫芽球性T細胞リンパ腫−病理・病態・治療．医のあゆみ 234: 549-554, 2010.
12) Yang QX, Pei XJ, et al : Secondary cutaneous Epstein-Barr virus-associated diffuse large B-cell lymphoma in a patient with angioimmunoblastic T-cell lymphoma: a case report and review of literature. Diagn Pathol doi: 10.1186/1746-1596-7-7, 2012. Accessed July 21, 2016.
8) 平賀幸弘， 黄　純一， 他：頸部原発の血管免疫芽球性T細胞リンパ腫の1症例．日耳鼻 116: 1114-1119, 2013.
4) Niitsu N, Okamoto M, et al : Clinico-pathologic features and outcome of Japanese patients with peripheral T-cell lymphomas. Hematol Oncol 26: 152-158, 2008.
19) Ogura M, Ishida T, et al : Multicenter phase II study of mogamulizumab (KW-0761), a defucosylated anticc chemokine receptor 4 antibody, in patients with relapsed peripheral T-cell lymphoma and cutaneous T-cell lymphoma. J Clin Oncol 32: 1157-1163, 2014.
5) Dogan A, Attygalle AD, et al : Angioimmunoblastic T-cell lymphoma. Br J Haematol 121: 681-691, 2003.
References_xml – reference: 6) 鈴木律朗：T/NK細胞リンパ腫ガイドライン．臨血 54: 1764-1769, 2013.
– reference: 21) Argyris PP, Koutlas IG, et al : Angioimmunoblastic T-cell lymphoma of the oral cavity presenting as gingival mass : report of the histopathologic and molecular characteristics of an unusual case featuring clonal T-cell receptor γ gene rearrangement by polymerase chain reaction. Oral Surg Oral Med Oral Pathol Oral Radiol 118: e198-204, 2014.
– reference: 2) Federico M, Rudiger T, et al : Clinicopathologic characteristics of angioimmunoblastic T-cell lymphoma : analysis of the international peripheral T-cell lymphoma project. J Clin Oncol 23: 240-246, 2013.
– reference: 8) 平賀幸弘， 黄　純一， 他：頸部原発の血管免疫芽球性T細胞リンパ腫の1症例．日耳鼻 116: 1114-1119, 2013.
– reference: 12) Yang QX, Pei XJ, et al : Secondary cutaneous Epstein-Barr virus-associated diffuse large B-cell lymphoma in a patient with angioimmunoblastic T-cell lymphoma: a case report and review of literature. Diagn Pathol doi: 10.1186/1746-1596-7-7, 2012. Accessed July 21, 2016.
– reference: 14) Wang Y, Xie B, et al : Development of angioimmunoblastic T-cell lymphoma after treatment of diffuse large B-cell lymphoma: a case report and review of literature. Int J Clin Exp Pathol 7: 3432-3438, 2014.
– reference: 9) 岡本昌隆：血管免疫芽球性T細胞リンパ腫−病理・病態・治療．医のあゆみ 234: 549-554, 2010.
– reference: 15) Suefuji N, Niino D, et al : Clinicopathological analysis of a composite lymphoma containing both T- and B-cell lymphomas. Pathol Int 62: 690-698, 2012.
– reference: 3) The world health organization classification of malignant lymphomas in japan : incidence of recently recognized entities. Lymphoma Study Group of Japanese Pathologists. Pathol Int 50: 696-702, 2000.
– reference: 4) Niitsu N, Okamoto M, et al : Clinico-pathologic features and outcome of Japanese patients with peripheral T-cell lymphomas. Hematol Oncol 26: 152-158, 2008.
– reference: 5) Dogan A, Attygalle AD, et al : Angioimmunoblastic T-cell lymphoma. Br J Haematol 121: 681-691, 2003.
– reference: 17) Ishida T, Utsunomiya A, et al : Clinical significance of CCR4 expression in adult T-cell leukemia/lymphoma: its close association with skin involvement and unfavorable outcome. Clin Cancer Res 9: 3625-3634, 2003.
– reference: 19) Ogura M, Ishida T, et al : Multicenter phase II study of mogamulizumab (KW-0761), a defucosylated anticc chemokine receptor 4 antibody, in patients with relapsed peripheral T-cell lymphoma and cutaneous T-cell lymphoma. J Clin Oncol 32: 1157-1163, 2014.
– reference: 11) 田丸淳一， 川野竜太郎， 他：悪性リンパ腫の病理．日耳鼻 112: 465-473, 2009.
– reference: 1) 青笹克之， 森井英一：血管免疫芽球性T細胞リンパ腫；リンパ球増殖疾患　癌診療指針のための病理診断プラクティス．中山書店， 東京， 2010, 227-235 頁．
– reference: 20) Attygalle AD, Kyriakou C, et al : Histologic evolution of angioimmunoblastic T-cell lymphoma in consecutive biopsies: clinical correlation and insights into natural history and disease progression. Am J Surg Pathol 31: 1077-1088, 2007.
– reference: 13) Yang G, Abdelhalim F, et al : Composite Angioimmunoblastic T-Cell Lymphoma and B-Cell Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Involving Both Lymph Node and Bone Marrow With Digital Gangrene. Hematopathology 3: 14-21, 2018.
– reference: 7) (一社) 日本血液学会：末梢性T細胞リンパ腫．造血器腫瘍診療ガイドライン : 2013. Available at: http://www.jshem.or.jp/gui-hemali/2_7.html Accessed August 20, 2016.
– reference: 10) 伊豆津宏二：血管免疫芽球性T細胞リンパ腫．Nippon Rinsho 72: 519-523, 2014.
– reference: 16) 義江　修：ケモカイン受容体CCR4とHTLV-1感染，ATL発がん. ウイルス 58: 125-140, 2008.
– reference: 18) Ishida T, Inagaki H, et al : CXC chemokine receptor 3 and CC chemokine receptor 4 expression in T-cell and NK-cell lymphomas with special reference to clinicopathological significance for peripheral T-cell lymphoma, unspecified. Clin Cancer Res 10: 5494-5500, 2004.
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Snippet Angioimmunoblastic T-cell lymphoma (AITL) is one of the subtypes of non-Hodgkin lymphoma. The neoplasm is characterized by aggressive, rapid growth and a poor...
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SubjectTerms 血管免疫芽球性Ｔ細胞リンパ腫
顎下リンパ節
Title 顎下リンパ節の腫脹を契機に診断に至った血管免疫芽球性T細胞リンパ腫の1例
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